Encontrados 2 documentos, a visualizar página 1 de 1
Koolen-de Vries syndrome – National Case Series with clinical and molecular cha...
Soares, Marta P.; Rodrigues, Márcia; Dupont, Juliette; Medeira, Ana; Freixo, João; Nunes, Sofia; Cordeiro, Isabel; Travessa, André; Soares, GabrielaIntroduction: Koolen-de Vries Syndrome (KdVS) is a rare genetic condition, caused by a 17q21.31 microdeletion, or a pathogenic variant in KANSL1 gene. The clinical picture includes developmental delay (DD)/intellectual disability (ID) with expressive language particularly impaired, dysmorphisms, neonatal hypotonia, and friendly behaviour. Aim: To characterize at the molecular and clinical levels all patients in...
Stroma-derived IL-6, G-CSF and Activin-A mediated dedifferentiation of lung car...
Rodrigues, Carlos F. D.; Serrano, Eurico; Patrício, Maria I.; Val, Mariana; Albuquerque, Patrícia; Fonseca, João; Gomes, Célia M. F.; Abrunhosa, AnteroCancer stem cells (CSCs) are a small population of resistant cells inhabiting the tumors. Although comprising only nearly 3% of the tumor mass, these cells were demonstrated to orchestrate tumorigenesis and differentiation, underlie tumors' heterogeneity and mediate therapy resistance and tumor relapse. Here we show that CSCs may be formed by dedifferentiation of terminally differentiated tumor cells under stre...