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Caracterização Epidemiológica do Carcinoma Ocular de Células Escamosas em bovin...

Bilhastre, Beatriz; Silveira, Mário; Fagundes, João; Vala, Helena; Branco, Sandra; Pinto, Carlos

O Carcinoma Ocular de Células Escamosas (COCE) é uma neoplasia maligna primária com origem nos queratinócitos, afetando principalmente a terceira pálpebra. Considerada a neoplasia ocular mais comum em bovinos, causa um elevado impacto económico devido a rejeições de carcaças em matadouro, custos com o tratamento e diminuição da produção. Bovinos idosos das raças Bos Taurus sem pigmentação periocular expostos co...


Hepatocellular Early Apoptosis Associated with HES 130/0.4 Administration for V...

Vala, Helena; Faustino-Rocha, Ana I; Curz, Rita; Venâncio, Carlos; Silva, Aura; Mesquita, João R; Ortiz, Ana L; Ferreira, David A

Hydroxyethyl starch 130/0.4 is a colloid solution used for expanding the plasma volume in situations of severe hypotension that, for example, may result from acute severe blood loss. This volume expansion allows for a more adequate organ perfusion, and consequent oxygen and nutrient delivery to the tissues. Nevertheless, several secondary effects associated with the hydroxyethyl starch 130/0.4 administration ha...


PCR-Based Detection of Bovine Papillomavirus Type 1 (BPV-1) in Ocular Squamous ...

Bilhastre, Beatriz; Pinto, Carlos; Vala, Helena; Mascarenhas, Paulo; Branco, Sandra; Ribeiro, Ana Clara

Bovine Ocular Squamous Cell Carcinoma (BOSCC) is the most prevalent ocular malignancy in cattle, primarily affecting the nictitating membrane but also involving other ocular and periocular structures, including the cornea, sclera, eyelids, third eyelid, limbus, and conjunctiva. Originating from keratinocytes, BOSCC is a significant cause of economic loss due to carcass rejection, increased veterinary costs, and...


Pulmonary and Gastrointestinal Parasitic Infections in Small Ruminant Autochtho...

Pereira, Maria; Vila-Viçosa, Maria João M.; Coelho, Catarina; Santos, Carla; Esteves, Fernando; Cruz, Rita; Gomes, Liliana; Henriques, Diogo

The production of small ruminant autochthonous breeds in the Centre region of Portugal is practiced in a semi-extensive husbandry system, exposing animals to parasitic infections. The main objective of this study was to estimate the prevalence of lungworm infection and identify risk factors. Fecal samples of 203 goats and 208 sheep from 30 herds were collected per rectum and subjected to the modified Baermann t...

Date: 2024   |   Origin: Biblioteca Digital do IPB

Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesi...

Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana; Silva, Jessica; Silva, Mónica; Pires, Maria João; Neuparth, Maria João; Vala, Helena

Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, WT, 0...

Date: 2024   |   Origin: Biblioteca Digital do IPB

Exploring the therapeutic potential of Quercus ilex acorn extract in papillomav...

Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Vasconcelos-Nóbrega, Cármen; Gouvinhas, Irene

Papillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have several unexplored ...

Date: 2024   |   Origin: Biblioteca Digital do IPB

Molecular evidence of sporadic Coxiella burnetii excretion in sheep milk, centr...

Pires, Humberto; Santos-Silva, Sérgio; Cruz, Andreia V.S.; Cardoso, Luís; Lopes, Ana Patrícia; Pereira, Maria; Nóbrega, Carmen; Mega, Cristina

Coxiella burnetii is the etiologic agent of Q fever, a worldwide zoonosis. Cattle, sheep and goats are considered the main reservoirs of the disease. Transmission to humans occurs mainly through the inhalation of infectious aerosols from milk, faeces, urine, and birth products from infected ruminants. In this study, a 2-year longitudinal approach was performed to ascertain the excretion of C. burnetii in bulk t...


Pulmonary and Gastrointestinal Parasitic Infections in Small Ruminant Autochtho...

Pereira, Maria; Vila-Viçosa, Maria; Coelho, Catarina; Santos, Carla; Esteves, Fernando; Cruz, Rita; Gomes, Liliana; Henriques, Diogo; Vala, Helena

The production of small ruminant autochthonous breeds in the Centre region of Portugal is practiced in a semi-extensive husbandry system, exposing animals to parasitic infections. The main objective of this study was to estimate the prevalence of lungworm infection and identify risk factors. Fecal samples of 203 goats and 208 sheep from 30 herds were collected per rectum and subjected to the modified Baermann t...


Exploring the therapeutic potential of Quercus ilex acorn extract in papillomav...

Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Nóbrega, Carmen; Gouvinhas, Irene

Background and Aim: Papillomaviruses (PVs) infections have been documented in numerous animal species across different regions worldwide. They often exert significant impacts on animal health and livestock production. Scientists have studied natural products for over half a century due to their diverse chemical composition, acknowledging their value in fighting cancer. Acorns (Quercus ilex) are believed to have...


Aloysia citrodora extract as a chemopreventive agent against HPV16-induced lesi...

Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I.; Silva, Jéssica; Silva, Mónica G.; Pires, Maria João; Neuparth, Maria João; Vala, Helena

Aim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...


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