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Reactivation of latent HIV-1 in vitro using an ethanolic extract from Euphorbia...

Valadão, Ana Luiza Chaves; Pezzuto, Paula; Silva, Viviane A Oliveira; Gonçalves, Barbara Simonson; Rossi, Átila Duque; da Cunha, Rodrigo Delvecchio

Euphorbia umbellata (E. umbellata) belongs to Euphorbiaceae family, popularly known as Janauba, and its latex contains a combination of phorbol esters with biological activities described to different cellular protein kinase C (PKC) isoforms. Here, we identified deoxi-phorbol esters present in E. umbellata latex alcoholic extract that are able to increase HIV transcription and reactivate virus from latency mode...

Date: 2018   |   Origin: RepositóriUM - Universidade do Minho
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