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Systemic inflammation as a risk factor for portal vein thrombosis in cirrhosis:...

Nery, F; Carneiro, P; Correia, S; Macedo, C; Gandara, J; Lopes, V; Valadares, D; Ferreira, S; Oliveira, J; Teixeira Gomes, M; Miranda, HP; Rautou, PE

Background and Aims Various risk factors for portal vein thrombosis (PVT) development in patients with cirrhosis have been identified, but the role of systemic inflammatory reaction is unknown. The study aims to assess the association between markers of systemic inflammation and PVT in cirrhosis. Methods Between January 2014 and October 2015, 107 outpatients with cirrhosis and no PVT were recruited, and followe...


Pleural Effusion Related to Chronic Hepatitis B Virus Reactivation: A Rare Asso...

Oliveira, A; Valadares, D; Nery, F

Despite worldwide vaccination campaigns, hepatitis B virus (HBV) infection remains a major public health problem. The natural history ranges from asymptomatic infection to severe liver injury or failure, chronic complications or reactivation episodes. The effects of HBV on the organism are immunomediated, possibly triggering extrahepatic manifestations. Since 1971, only a few cases of pleural effusion related t...


The Role of a Medical Intermediate Care Unit in the Management of Budd-Chiari S...

Cravo, M; Oliveira, DG; Guimas, A; Vita, P; Rego, AL; Alves, R; Valadares, D; Carvalheiras, G; Ricardo, M; Pinto, A; Pessegueiro, H; Nery, F

Budd-Chiari syndrome (BCS) has a wide spectrum of presentations, from an asymptomatic status to acute liver failure (ALF). The therapeutic approach depends on disease severity and related etiology with patients with severe forms of presentation classically managed in intensive care units (ICUs). Here, we report a series of five BCS patients managed in a medical intermediate care unit (IntCU), with three of them...


Nonselective beta-blockers and the risk of portal vein thrombosis in patients w...

Nery, F; Correia, S; Macedo, C; Gandara, J; Lopes, V; Valadares, D; Ferreira, S; Oliveira, J; Gomes, MT; Lucas, R; Rautou, PE; Miranda, HP; Valla, D

Background Nonmalignant portal vein thrombosis is a significant event in the course of cirrhosis that can contraindicate liver transplantation and even impact survival after the surgical procedure. Risk factors are not completely known or validated and are still debated. Aim To identify in patients with cirrhosis the risk factors for portal vein thrombosis that are assessable in clinical practice. Methods Betwe...


Efficacy and Safety of Direct-Acting Oral Anticoagulants Use in Acute Portal Ve...

Nery, F; Valadares, D; Morais, S; Gomes, MT; de Gottardi, A

In acute portal vein thrombosis (APVT) unrelated to cirrhosis, anticoagulant therapy is classically started with low molecular weight heparin or vitamin K antagonists. New direct-acting oral anticoagulants (DOACs) are used in the treatment of venous thrombosis outside the splanchnic vascular bed, but not in the latter. We report a young female with APVT occurring in a non-cirrhotic liver linked to heterozygosit...


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