5 documents found, page 1 of 1
HIV-2 infection is associated with preserved GALT homeostasis and epithelial in...
Fernandes, S; Pires, A; Matoso, P; Ferreira, C; Nunes-Cabaço, H; Correia, L; Valadas, E; Poças, J; Pacheco, P, et al.The mechanisms that enable preservation of gut mucosal integrity during persistent viral replication and inherent inflammation remain unclear. Here, we investigated, for the first time, gut homeostasis in HIV-2 infection, a naturally occurring form of attenuated HIV disease. We found viral replication in both sigmoid and ileum of asymptomatic HIV-2+ patients (range: 240-851 circulating CD4+T-cells per μl) despi...
The Demise of Multidrug-Resistant HIV-1: the National Time Trend in Portugal
Vercauteren, J; Theys, K; Carvalho, AP; Valadas, E; Duque, LM; Teófilo, E; Faria, T; Faria, D; Vera, J; Aguas, MJ; Peres, S; Mansinho, K; Vandamme, AMOBJECTIVES: Despite a decreasing mortality and morbidity in treated HIV-1 patients, highly active antiretroviral treatment (HAART) can still fail due to the development of drug resistance. Especially, multidrug-resistant viruses pose a threat to efficient therapy. We studied the changing prevalence of multidrug resistance (MDR) over time in a cohort of HIV-1-infected patients in Portugal. PATIENTS AND METHODS: ...
Population mobility and the changing epidemics of HIV-2 in Portugal
Carvalho, A; Valadas, E; França, L; Carvalho, C; Aleixo, M; Mendez, J; Marques, R; Sarmento, A; Doroana, M; Antunes, F; Branco, T; Águas, M; Castro, RINTRODUCTION: Portugal is the European country with the highest frequency of HIV-2 infection, which is mainly concentrated in West Africa. The cumulative number of notified HIV-2 infections in Portugal was 1813 by the end of December 2008. To better characterize the dynamics of HIV-2 infection in the country and to obtain data that may be of use in the prevention of the spread of HIV-2, we evaluated a large poo...
Population mobility and the changing epidemics of HIV-2 in Portugal
Carvalho, AC; Valadas, E; França, L; Carvalho, C; Aleixo, MJ; Mendez, J; Marques, R; Sarmento, A; Doroana, M; Antunes, F; Branco, T; Águas, MIntroduction: Portugal is the European country with the highest frequency of HIV-2 infection, which is mainly concentrated in West Africa. The cumulative number of notified HIV-2 infections in Portugal was 1813 by the end of December 2008. To better characterize the dynamics of HIV-2 infection in the country and to obtain data that may be of use in the prevention of the spread of HIV-2, we evaluated a large poo...
Neurosyphilis and AIDS.
Quaresma, M J; Valadas, E; Ferreira, J JSyphilis in HIV-infected patients reveals some particular aspects which are clinically relevant and disturbing: it is more frequent and develops more quickly to late stages, namely neurosyphilis; this progression may happen even if classic therapy in the early stages has been undertaken; the diagnosis of neurosyphilis is rather complex, the serological tests being of no definite credit; high doses of intravenou...