21 documents found, page 1 of 3
Three misconceptions in medical education: student evaluation of teaching, curr...
Hanscheid, Thomas; Valadas, Emília; Costa, JoãoThree widely held assumptions in medical education may inadvertently hinder effective learning. First, student evaluations of teaching (SETs) are often treated as proxies for educational quality, yet they are shaped by factors unrelated to actual learning and provide limited actionable insight. Second, repetition in the curriculum is frequently dismissed as poor design rather than recognised as essential for ma...
Disease Caused by Filoviruses: An Update
Marx de Andrade, Rafael; Paulos, Andreia; Valadas, Emília; Laerte Pinto Junior, VitorThe Marburg and Ebola viruses belong to the Filoviridae family and are known to cause emerging zoonotic diseases. These viruses have a high case fatality rate and are easily transmissible from person to person, which makes them capable of triggering outbreaks, including in non-endemic regions, and are also considered agents of bioterrorism. Fruit bats are the natural reservoirs of these filoviruses. Transmissio...
Combating Vaccine Hesitancy Requires Knowledge of Misfortunes and Controversies
Pinto Junior, Vitor Laerte; Valadas, Emília; Hanscheid, ThomasN/a.; N/a.
Antibody response against selected epitopes in the HIV-1 envelope gp41 ectodoma...
Marcelino, Rute; Gramacho, Filipa; Martin, Francisco; Brogueira, Pedro; Janeiro, Nuno; Afonso, Cláudia; Badura, Robert; Valadas, Emília; Mansinho, KamalThe ectodomain of gp41 is the target of potent binding and neutralizing antibodies (NAbs) and is being explored in new strategies for antibody-based HIV vaccines. Previous studies have suggested that the W164A-3S (3S) and EC26-2A4 (EC26) peptides located in the gp41 ectodomain may be potential HIV vaccine candidates. We assessed 3S- and EC26-specific binding antibody responses and related neutralizing activity ...
SARS-CoV-2 and Cancer: Beyond Immunosuppression
Mendes Pedro, Diogo; Mendes Pedro, Marta Maria; Valadas, Emília; Hanscheid, ThomasN/a.; N/a.
Coronavirus 2019-nCoV: is the genie already out of the bottle?
Hanscheid, Thomas; Valadas, Emília; Grobusch, Martin P.Once again, a virus has jumped the species barrier. Coronavirus 2019-nCoV emerged apparently in a wet market in China, and after a few weeks the number of cases already exceeds those of SARS in 2002/03 (Fig. 1) in terms of both morbidity and mortality. Excellent publications have addressed many aspects of a possible novel endemic/pandemic zoonosis, often with a focus on MERS-CoV (2–4), includingprevention, drug...
Cardiovascular risk in HIV-infected individuals: a comparison of three risk pre...
Policarpo, Sara; Rodrigues, Teresa; Moreira, Ana Catarina; Valadas, EmíliaABSTRACT - Introduction: Cardiovascular (CV) risk is known to be increased in HIV-infected individuals. Our aim was to assess CV risk in HIV-infected adults. Methods: CV risk was estimated for each patient using three different risk algorithms: SCORE, the Framingham risk score (FRS), and DAD. Patients were classified as at low, moderate or high CV risk. Clinical and anthropometric data were collected. Results: ...
Cardiovascular risk in HIV-infected individuals : a comparison of three risk pr...
Policarpo, Sara; Rodrigues, Teresa; Moreira, Ana Catarina; Valadas, EmíliaIntroduction: Cardiovascular (CV) risk is known to be increased in HIV-infected individuals. Our aim was to assess CV risk in HIV-infected adults. Methods: CV risk was estimated for each patient using three different risk algorithms: SCORE, the Framingham risk score (FRS), and DAD. Patients were classified as at low, moderate or high CV risk. Clinical and anthropometric data were collected. Results: We included...
Potency of HIV-2-specific antibodies increase in direct association with loss o...
Rocha, Cheila; Duarte, Joana; Borrego, Pedro; Calado, Rita; Marcelino, José Maria; Tendeiro, Rita; Valadas, Emília; Sousa, Ana Espada; Taveira, NunoPotent HIV-neutralizing antibodies are critical for vaccination and viral reservoir control. High levels of neutralizing antibodies characterize HIV-2 infection, a naturally occurring model of attenuated HIV disease with low-to-undectable viremia. We found that HIV-2-specific antibody potency increased in direct association with the loss of both switched and unswitched memory B cells in untreated HIV-2 infectio...
Adherence to Mediterranean diet in HIV infected patients: relation with nutriti...
Policarpo, Sara; Rodrigues, Teresa; Moreira, Ana Catarina; Valadas, EmíliaBackground & aims: The Mediterranean diet (MedDiet) has been associated to a lower prevalence of metabolic syndrome (MS) and a lower cardiovascular risk (CVR). Our aim was to assess HIV infected individual's adherence to the MedDiet and its relationship with nutritional status and CVR. Methods: Clinical and anthropometric data were collected and a nutritional assessment was performed. Adherence to the MedDiet w...