12 documents found, page 1 of 2
Comprehensive perspective for lung cancer characterisation based on AI solution...
Pereira, T; Freitas, C; Costa, JL; Morgado, J; Silva, F; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, V; Cunha, A; Oliveira, HPLung cancer is still the leading cause of cancer death in the world. For this reason, novel approaches for early and more accurate diagnosis are needed. Computer-aided decision (CAD) can be an interesting option for a noninvasive tumour characterisation based on thoracic computed tomography (CT) image analysis. Until now, radiomics have been focused on tumour features analysis, and have not considered the infor...
Sharing biomedical data: Strengthening ai development in healthcare
Pereira, T; Morgado, J; Silva, F; Pelter, MM; Dias, VR; Barros, R; Freitas, C; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, VArtificial intelligence (AI)-based solutions have revolutionized our world, using extensive datasets and computational resources to create automatic tools for complex tasks that, until now, have been performed by humans. Massive data is a fundamental aspect of the most powerful AI-based algorithms. However, for AI-based healthcare solutions, there are several socioeconomic, technical/infrastructural, and most i...
EGFR Assessment in Lung Cancer CT Images: Analysis of Local and Holistic Region...
Silva, F; Pereira, T; Morgado, J; Frade, J; Mendes, J; Freitas, C; Negrao, E; Lima, BF; Silva, M; Madureira, AJ; Ramos, I; Hespanhol, V; Costa, JLStatistics have demonstrated that one of the main factors responsible for the high mortality rate related to lung cancer is the late diagnosis. Precision medicine practices have shown advances in the individualized treatment according to the genetic profile of each patient, providing better control on cancer response. Medical imaging offers valuable information with an extensive perspective of the cancer, openi...
Machine learning and feature selection methods for egfr mutation status predict...
Morgado, J; Pereira, T; Silva, F; Freitas, C; Negrão, E; Lima, BF; Silva, MC; Madureira, AJ; Ramos, I; Hespanhol, V; Costa, JL; Cunha, A; Oliveira, HPThe evolution of personalized medicine has changed the therapeutic strategy from classical chemotherapy and radiotherapy to a genetic modification targeted therapy, and although biopsy is the traditional method to genetically characterize lung cancer tumor, it is an invasive and painful procedure for the patient. Nodule image features extracted from computed tomography (CT) scans have been used to create machin...
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs again...
Gaspar, L; Coron, R; KongThoo Lin, P; Costa, DM; Perez-Cabezas, B; Tavares, J; Roura-Ferrer, M; Ramos, I; Ronin, C; Major, L; Ciesielski, FChagas disease remains one of the most neglected diseases in the world despite being the most important parasitic disease in Latin America. The characteristic chronic manifestation of chagasic cardiomyopathy is the region’s leading cause of heart-related illness, causing significant mortality and morbidity. Due to the limited available therapeutic options, new drugs are urgently needed to control the disease. S...
LRP5 gene polymorphisms and radiographic joint damage in rheumatoid arthritis p...
Bernardes, M; Durães, C; Oliveira, A; Martins, MJ; Lucas, R; Costa, L; Pereira, JG; Ramos, I; Machado, JC; Simões-Ventura, FRheumatoid arthritis (RA) is characterized by increased bone resorption and impaired bone formation. Osteoblast function is regulated by the canonical LRP5/Wnt/-catenin pathway. Bone mineral density and RA joint destruction are partially inherited. In line with this, we found significant associations between LRP5 SNPs (p.A1330V, p.N740N, p.V667M) and RA radiographic damage severity.IntroductionIncreased bone re...
Activity of bisnaphthalimidopropyl derivatives against trypanosoma brucei
Loureiro, I; Thoo-Lin, P; Ramos, I; Roura, M; Pruvost, A; Pemberton, I; Loukil, H; MacDougall, J; Tavares, J; Cordeiro-da-Silva, A; Graça, NA; Gaspar, LCurrent treatments for African trypanosomiasis are either toxic, costly, difficult to administer, or prone to elicit resistance. This study evaluated the activity of bisnaphthalimidopropyl (BNIP) derivatives against Trypanosoma brucei. BNIPDiaminobutane (BNIPDabut), the most active of these compounds, showed in vitro inhibition in the single-unit nanomolar range, similar to the activity in the reference drug pe...
Diffusion-weighted imaging: determination of the best pair ofb-values to discri...
Nogueira, Luisa; Brandão, S; Matos, E; Nunes, R G; Loureiro, J; Ferreira, H A; Ramos, IIn breast diffusion-weighted imaging (DWI), the apparent diffusion coefficient (ADC) is used to discriminate between malignant and benign lesions. As ADC estimates can be affected by the weighting factors, our goal was to determine the optimal pair of b-values for discriminating breast lesions at 3.0 T. METHODS: 152 females with 157 lesions (89 malignant and 68 benign) underwent breast MRI, including a DWI sequ...
Cervical abscess in an immunocompetent patient with Mycobacterium malmoense pul...
Duarte, JN; Marques, N; Barroso, L; Ramos, I; Sá, R; Sanz, D; Ferreira, A; Saraiva da Cunha, JGBACKGROUND: Mycobacterium malmoense is a nontuberculous mycobacteria seen mainly in two age groups and with different clinical presentations. Most patients are male adults presenting clinical symptoms and signs similar to those of pulmonary tuberculosis. The second group is formed by immunocompetent children with localized cervical lymphadenitis. Although cervical adenitis is the main extrapulmonary manifestati...
CD26/DPPIV and response to hepatitis B vaccination
Dourado, M; Alves, V; Mesquita, L; Ramos, I; Pinto, AM; Rosa, MSThe prevention of hepatitis B is important, since it is responsible for significant morbidity and mortality around the world. Unfortunately, hepatitis B vaccine does not always induce protective immunity. The lack of immune response to vaccine (non-responders) can depend on individual characteristics. The objective of this study was to correlate the CD26/DPPIV cellular expression and DPPIV serum activity with H...