10 documents found, page 1 of 1
Chitosan/hydroxyethyl cellulose inserts for sustained-release of dorzolamide fo...
Juçara Ribeiro França; Giselle Foureaux; Leonardo Lima Fuscaldi; Tatiana Gomes Ribeiro; Rachel Oliveira Castilho; Maria Irene YoshidaCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico; FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais; CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Eye drops containing hydrophilic drugs are commonly used to reduce intraocular pressure (IOP) in glaucoma patients, but compliance to the treatement is commonly reduced by frequent dosing and eventual systemi...
Probiotic Propionibacterium freudenreichii requires SlpB protein to mitigate mu...
Fillipe Luiz Rosado Carmo; Houem Rabah; Barbara Fernandes Cordeiro; Sara Heloisa da Silva; Rafaela Miranda Pessoa; Simone Odília Antunes FernandesOutra Agência; Propionibacterium freudenreichii CIRM-BIA 129 (P. freudenreichii wild type, WT) is a probiotic bacterium, which exerts immunomodulatory effects. This strain possesses extractable surface proteins, including SlpB, which are involved in anti-inflammatory effect and in adhesion to epithelial cells. We decided to investigate the impact of slpB gene mutation on immunomodulation in vitro and in vivo. I...
Circulating leptin levels as a potential biomarker in inflammatory bowel diseas...
Larissa Gabriela Ferreira de Carvalho; William Gustavo Lima; Luiz Gonzaga Vaz Coelho; Valbert Nascimento Cardoso; Simone Odília Antunes FernandesCAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Background The differential diagnosis of inflammatory bowel diseases (IBDs) between Crohn’s disease (CD) and ulcerative colitis (UC) is important for designing an effective therapeutic regimen. However, without any adequate gold standard method for differential diagnosis currently, therapeutic design remains a major challenge in clinical pract...
Evaluation of antitumor activity and cardiac toxicity of a bone-targeted ph-sen...
Diego dos Santos Ferreira; Bruno Luís Jesus de Oliveira Pinto; Vidhya Kumar; Valbert Nascimento Cardoso; Simone Odília Fernandes; Cristina Maria SouzaChemotherapy for bone tumors is a major challenge because of the inability of therapeutics to penetrate dense bone mineral. We hypothesize that a nanostructured formulation with high affinity for bone could deliver drug to the tumor while minimizing off-target toxicity. Here, we evaluated the efficacy and toxicity of a novel bone-targeted, pH-sensitive liposomal formulation containing doxorubicin in an animal m...
Shortened derivatives from native antimicrobial peptide LyeTx I: in vitro and i...
Leonardo Lima Fuscaldi; Joaquim Teixeira de Avelar Júnior; Daniel Moreira dos Santos; Daiane Boff; Vívian Louise Soares de OliveiraCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico; FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais; CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; In the continuing search for novel antibiotics, antimicrobial peptides are promising molecules, due to different mechanisms of action compared to classic antibiotics and to their selectivity for interaction w...
(1 → 3)-β-D-glucan aptamers labeled with technetium-99 m: Biodistribution and i...
Camila Maria de Sousa Lacerda; Iêda Mendes Ferreira; Sara Roberta dos Santos; André Luís Branco de Barros; Simone Odília FernandesCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico; FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais; Outra Agência; Introduction Acid nucleic aptamers are RNA or DNA oligonucleotides capable of binding to a target molecule with high affinity and selectivity. These molecules are promising tools in nuclear medicine. Many aptamers have been used as targeting molecule of radiopha...
Synthesis and antimicrobial evaluation of two peptide LyeTx I derivatives modif...
Leonardo Lima Fuscaldi; Daniel Moreira Dos Santos; Natália Gabriela Silva Pinheiro; Raquel Silva Araújo; André Luís Branco de BarrosBackground: Current diagnostic methods and imaging techniques are not able to differentiate septic and aseptic inflammation. Thus, reliable methods are sought to provide this distinction and scintigraphic imaging is an interesting option, since it is based on physiological changes. In this context, radiolabeled antimicrobial peptides have been investigated as they accumulate in infectious sites instead of asept...
Influence of biomaterials on scintigraphic diagnosis of periprosthetic infectio...
Luiz Eduardo Moreira Teixeira; Bruno Jannotti Pádua; André Moreira Castilho; Ivana Duval de Araújo; Marco Antônio Percope de AndradePurpose: To compare the influence of two metallic implants in the diagnosis of periprosthetic infection using 99m technetium-labeled ceftizoxime. Methods: Twenty rats were randomly divided into four groups, which received sterile and contaminated titanium and stainless steel implants. After 3 weeks, scintilographic images were obtained using a gamma chamber. Radioactivity counts were obtained for the region of ...
Vagus nerve regulates the phagocytic and secretory activity of resident macroph...
Roberta Cristelli Fonseca; Gabriel Shimizu Bassi; Camila Carvalho Brito; Lorena Barreto Rosa; Bruna Araújo David; Alan Moreira Araújo; Natália NóbregaCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico; FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais; CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; The gastrointestinal (GI) tract harbors commensal microorganisms as well as invasive bacteria, toxins and other pathogens and, therefore, plays a pivotal barrier and immunological role against pathogenic agen...
A new method for studying cryptococcosis in a murine model using 99mTc-Cryptoco...
Marliete Carvalho Costa; Lays Murta Mata; Noelly de Queiroz Ribeiro; Anderson Philip Nonato Santos; Lorena Vivien Neves OliveiraCNPq - Conselho Nacional de Desenvolvimento Científico e Tecnológico; FAPEMIG - Fundação de Amparo à Pesquisa do Estado de Minas Gerais; CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; Cryptococcus gattii is one of the etiologic agents of cryptococcosis, a systemic mycosis that occurs in healthy and immunosuppressed humans and animals worldwide. Primary pulmonary infection caused by C. gatt...