68 documents found, page 1 of 7
Occupational exposure to wildland firefighting and its effects on systemic DNA ...
Esteves, Filipa; Madureira, Joana; Costa, Carla Sofia; Pires, Joana; Barros, Bela; Alves, Sara; Vaz, Josiana A.; Oliveira, Marta; Slezakova, KlaraPortugal is among the European Union countries more devastated by forest fires. Wildland fire- fighters are at the forefront of this battle, facing exposure to a wide range of harmful pollutants. Epidemiological studies have highlighted a potential link between occupational firefighting exposure and several diseases, including cancer. To date, very few studies have explored the biological mechanisms associated ...
Lifestyle, environment and other major determinants of frailty in older adults:...
Hemadeh, Ali; Lema-Arranz, Carlota; Bonassi, Stefano; Buscarini, Leonardo; Infarinato, Francesco; Romano, Paola; Finti, Alessia; Marinozzi, FrancoFrailty is a geriatric multidimensional syndrome characterized by a loss of physiologic reserves and disproportionate vulnerability to external stressors and associated with increased risk of multiple negative health outcomes. Since frailty can be prevented, controlled, and even reverted in its early stages, identifying the main factors involved in its development is crucial to implement preventive and/or resto...
Association of inflammatory biomarkers with physical and cognitive frailty in a...
Lema-Arranz, Carlota; Hemadeh, Ali; Fernández-Bertólez, Natalia; Cibeira, Nuria; López-López, Rocío; Costa, Solange; Millán-Calenti, José CarlosFrailty is a multifactorial geriatric syndrome characterized by increased vulnerability to stressors and associated with a higher risk of adverse health outcomes. Chronic low-grade inflammation has been proposed as a key pathophysiological mechanism underlying physical frailty, although its role in cognitive frailty remains undefined. In this cross-sectional study, we assessed the relationship between frailty s...
Association between cognitive reserve proxies and frailty phenotype: data from ...
Lorenzo-López, Laura; Cibeira, Nuria; Hemadeh, Ali; López-López, Rocío; Lema-Arranz, Carlota; Maseda, Ana; Fernández-Bertólez, Natalia; Costa, SolangeA potential protective role of cognitive reserve proxies against frailty has been suggested in older adults. We explored the cross-sectional association between cognitive reserve indicators and frailty phenotype. Data were obtained from the UK Biobank. We included 31,975 dementia-free participants aged ≥ 60 years (50.7% females, 2.2% frail) who completed a web-based cognitive assessment (fluid intelligence, wor...
Biocompatibility testing and antioxidant properties of cerium dioxide nanoparti...
Fernández-Bertólez, Natalia; Touzani, Assia; Ramos-Pan, Lucía; Reis, Ana Teresa; Teixeira, João Paulo; Laffon, Blanca; Valdiglesias, VanessaCerium dioxide nanoparticles (CeO NP), or nanoceria, are versatile materials with interesting properties for industry and medicine fields, particularly redox properties and catalytic activity. Because of their distinctive features, they have gained high attention in biomedical and pharmacological research to be employed in drug delivery, tissue regeneration, radioprotection, or diagnostic imaging. However, prev...
In vitro and in vivo assessment of nanoceria biocompatibility for their safe us...
Fernández-Bertólez, Natalia; Martínez, Luisa; Ramos-Pan, Lucía; Touzani, Assia; Costa, Carla; Laffon, Blanca; Valdiglesias, VanessaNanoceria, or cerium dioxide nanoparticles (CeO NP), are increasingly employed in a number of industrial and commercial applications. Hence, the environmental presence of these nanoparticles is growing progressively, enhancing the global concern on their potential health effects. Recent studies suggest that nanoceria may also have promising biomedical applications particularly in neurodegenerative and brain-rel...
Occupational exposure to wildland firefighting and its effects on systemic DNA ...
Esteves, Filipa; Madureira, Joana; Costa, Carla; Pires, Joana; Barros, Bela; Alves, Sara; Vaz, Josiana; Oliveira, Marta; Slezakova, KlaraBackground: Portugal is among the European Union countries more devastated by forest fires. Wildland firefighters are at the forefront of this battle, facing exposure to a wide range of harmful pollutants. Epidemiological studies have highlighted a potential link between occupational firefighting exposure and several diseases, including cancer. To date, very few studies have explored the biological mechanisms a...
Systematic review on toxicological effects of platinum nanoparticles: towards t...
Touzani, Assia; Ramos-Pan, Lucía; Fraga, Sónia; Fernández-Bertólez, Natalia; Laffon, Blanca; Valdiglesias, VanessaPlatinum nanoparticles (PtNP) have received considerable attention in the nanomedicine field due to their magnetic, catalytic, and optical properties. However, the potential toxicity of PtNP has not been properly evaluated yet, and current information on the possible risks related to their use is still limited. On this basis, the main objective of this systematic review was to gather available data on PtNP biol...
Occupational exposure to wildland firefighting and its effects on systemic DNA ...
Esteves, Filipa; Madureira, Joana; Costa, Carla; Pires, Joana; Barros, Bela; Alves, Sara; Vaz, Josiana; Oliveira, Marta; Slezakova, KlaraBackground: Portugal is among the European Union countries more devastated by forest fires. Wildland firefighters are at the forefront of this battle, facing exposure to a wide range of harmful pollutants. Epidemiological studies have highlighted a potential link between occupational firefighting exposure and several diseases, including cancer. To date, very few studies have explored the biological mechanisms a...
Impact of gold nanoparticle exposure on genetic material
Ramos-Pan, Lucía; Touzani, Assia; Fernández-Bertólez, Natalia; Fraga, Sónia; Laffon, Blanca; Valdiglesias, VanessaMetal nanoparticles, with gold nanoparticles (AuNP) at the forefront, have gained immense attention due to their unique properties. At the nanoscale, gold exhibits remarkable physical, chemical, optical, and electronic features, making it ideal for a plethora of applications, including bioimaging, sensing, diagnostics, and drug delivery. Despite their promising utility, concerns have arisen regarding the potent...