13 documents found, page 1 of 2
Durable and breathable ZnO/graphene-coated fabrics for enhanced BQR protection
Ferreira, Tânia; Vale, A. Catarina; Gonçalves, Afonso; Pinto, Alexandra C.; Sousa, Diana; Guimarães, Humberto; Moreira, Inês P.; Silva, CarlosThis work developed a new strategy to create active protection against chemical, biological, radiological and nuclear (CBRN) threats, based on polyurethane-based coatings for outer (water and oil-repellency) and inner (CBRN protection) functionalization of fabric. The internal coatings were functionalized with varying concentrations of zinc oxide nanoparticles (ZnO) and/or graphene nanoplatelets (Gf) and carefu...
Exploiting polyelectrolyte complexation for the development of adhesive and bio...
Fonseca, Mário C.; Vale, A. Catarina; Costa, Rui R.; Reis, R. L.; Alves, N. M.Mussels secrete protein-based byssal threads to tether to rocks, ships, and other organisms underwater. The secreted marine mussel adhesive proteins (MAPs) contain the peculiar amino acid L-3,4-dihydroxyphenylalanine (DOPA), whose catechol group content contributes greatly to their outstanding adhesive properties. Inspired by such mussel bioadhesion, we demonstrate that catechol-modified polysaccharides can be ...
Adhesive and biodegradable membranes made of sustainable catechol-functionalize...
Correia, Catia; Sousa, Rita Alexandra Oliveira; Vale, A. Catarina; Peixoto, Daniela; Silva, Tiago H.; Reis, R. L.; Pashkuleva, I.; Alves, N. M.We describe bioadhesive membranes developed from marine renewable biomaterials, namely chitosan and collagen extracted from fish skins. Collagen was functionalized with catechol groups (Coll-Cat) to provide the membranes with superior adhesive properties in a wet environment and blended with chitosan to improve the mechanical properties. The blended membranes were compared to chitosan and chitosan blended with ...
Poly(lactic acid)/graphite nanoplatelet nanocomposite filaments for ligament sc...
Silva, Magda; Gomes, Carina; Pinho, Isabel; Gonçalves, Hugo; Vale, A. Catarina; Covas, J. A.; Alves, N. M.; Paiva, Maria C.The anterior cruciate ligament (ACL) is one of the most prone to injury in the human body. Due to its insufficient vascularization and low regenerative capacity, surgery is often required when it is ruptured. Most of the current tissue engineering (TE) strategies are based on scaffolds produced with fibers due to the natural ligamentâ s fibrous structure. In the present work, composite filaments based on poly(L...
Spin-coated freestanding films for biomedical applications
Moreira, Joana; Vale, A. Catarina; Alves, N. M.Spin-coating is a widely employed technique for the fabrication of thin-film coatings over large areas with smooth and homogeneous surfaces. In recent years, research has extended the scope of spincoating by developing methods involving the interface of the substrate and the deposited solution to obtain self-supported films, also called freestanding films. Thereby, such structures have been developed for a wide...
Polymeric biomaterials inspired by marine mussel adhesive proteins
Vale, A. Catarina; Pereira, Paulo R.; Alves, N. M.Marine mussels have attracted attention in the last years due to their incredible ability to stick to various organic and inorganic substrates in harsh environments. This capacity has been attributed to specific proteins secreted by marine mussels, known as marine mussel adhesive proteins (MAPs). These proteins have in their constitution an unusual amino acid, 3,4-dihydroxyphenylalanine (DOPA). Many efforts hav...
3D‐printed cryomilled poly(ε‐caprolactone)/graphene composite scaffolds for bon...
Dias, Daniela; Vale, A. Catarina; Cunha, Eunice Paula Freitas; Paiva, M. C.; Reis, R. L.; Vaquette, Cedryck; Alves, N. M.In this study, composite scaffolds based on poly(caprolactone) (PCL) and non-covalently functionalized few-layer graphene (FLG) were manufactured by an extrusion-based system for the first time. For that, functionalized FLG powder was obtained through the evaporation of a functionalized FLG aqueous suspension prepared from a graphite precursor. Cryomilling was shown to be an efficient mixing method, producing a...
Layer-by-layer films based on catechol-modified polysaccharides produced by dip...
Almeida, Ana C.; Vale, A. Catarina; Pires, R. A.; Reis, R. L.; Alves, N. M.Layer-by-layer films based on chitosan and hyaluronic acid were produced by dip- and spin-coating techniques onto glass, 316L stainless steel and titanium. These natural polymers were modified with catechol groups, in order to build coatings with improved adhesive properties. Polymeric coatings were exclusively composed by both modified polymers whereas the multifunctional coatings combined an inorganic phase o...
Spin-coated polysaccharide-based multilayered freestanding films with adhesive ...
Moreira, Joana; Vale, A. Catarina; Pires, R. A.; Botelho, Gabriela; Reis, R. L.; Alves, N. M.Freestanding films based on catechol functionalized chitosan (CHI), hyaluronic acid (HA), and bioglass nanoparticles (BGNPs) were developed by spin-coating layer-by-layer assembly (SA-LbL). The catechol groups of 3,4-dihydroxy-<span style="font-variant: small-caps;">l</span>-phenylalanine (DOPA) present in the marine mussels adhesive proteins (MAPs) are the main factors responsible for their characteristic stro...
Bioactive and adhesive properties of multilayered coatings based on catechol-fu...
Almeida, Ana Catarina; Vale, A. Catarina; Reis, R. L.; Alves, N. M.Chitosan and hyaluronic acid are themost attractive natural polysaccharides used for tissue regeneration, herein innovative orthopedic coatings were constructed by dip-coating technique. Inspired by the tough nacre-like structure, multifunctional (MF) films were constructed using bioactive glass nanoparticles (BGNPs) as the inorganic phase and hyaluronic acid (HA) and chitosan (CHT) polymers as the organic phas...