2 documents found, page 1 of 1
Hypoxia and macrophages act in concert towards a beneficial outcome in colon ca...
Martins, F; Oliveira, R; Cavadas, B; Pinto, F; Cardoso, AP; Castro, F; Sousa, B; Pinto, ML; Silva, AJ; Adão, D; Loureiro, JP; Pedro, N; Reis, RMIn colon cancer, the prognostic value of macrophages is controversial, and it is still unknown how hypoxia modulates macrophage–cancer cell crosstalk. To unravel this, co-cultures of human primary macrophages and colon cancer cells were performed at 20% and 1% O2, followed by characterization of both cellular components. Different colon cancer patient cohorts were analyzed for hypoxia and immune markers, and th...
Macrophages down-regulate gene expression of intervertebral disc degenerative m...
Silva, AJ; Ferreira, JR; Cunha, C; Corte-Real, JV; Bessa-Gonçalves, M; Barbosa, MA; Santos, SG; Gonçalves, RMLow back pain is a highly prevalent clinical problem and intervertebral disc (IVD) degeneration is now accepted as the major pathophysiological mechanism responsible for this condition. Accumulating evidence suggests that inflammation plays a crucial role in the progression of human IVD degeneration, with macrophages being pointed as the key immune cell players in this process since their infiltration in degene...