34 documents found, page 1 of 4

Antimicrobial activity of prophage endolysins against critical Enterobacteriace...

Enterobacteriaceae species are part of the 2017 World Health Organization antibiotic-resistant priority pathogens list for development of novel medicines. Multidrug-resistant Klebsiella pneumoniae is an increasing threat to public health and has become a relevant human pathogen involved in life-threatening infections. Phage therapy involves the use of phages or their lytic endolysins as bioagents for the treatm...

Antimicrobial activity of prophage endolysins against critical Enterobacteriace...

Enterobacteriaceae species are part of the 2017 World Health Organization antibiotic-resistant priority pathogens list for development of novel medicines. Multidrug-resistant Klebsiella pneumoniae is an increasing threat to public health and has become a relevant human pathogen involved in life-threatening infections. Phage therapy involves the use of phages or their lytic endolysins as bioagents for the treatm...

Molecular detection of Helicobacter pyloriand its genotypic antimicrobial resis...

Background Helicobacter pylori strains show a high level of genotypic diversity and express several genes that contribute to their pathogenicity and resistance. In Mozambique, there is lack of information regarding its resistance pattern to antibiotics. In this study, we aimed to investigate the prevalence of H. pylori and its genotypic resistance to clarithromycin, metronidazole, and fluoroquinolones in Mozamb...

Molecular detection of Helicobacter pylori and its genotypic antimicrobial resi...

Background Helicobacter pylori strains show a high level of genotypic diversity and express several genes that contribute to their pathogenicity and resistance. In Mozambique, there is lack of information regarding its resistance pattern to antibiotics. In this study, we aimed to investigate the prevalence of H. pylori and its genotypic resistance to clarithromycin, metronidazole, and fluoroquinolones in Mozamb...

Author Correction: Repeated out-of-Africa expansions of Helicobacter pylori dri...

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement ...

Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori fromEurope and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori ...

Cryptic Prophages Contribution for Campylobacter jejuni and Campylobacter coli ...

Campylobacter coli and C. jejuni, the causing agents of campylobacteriosis, are described to be undergoing introgression events, i.e., the transference of genetic material between different species, with some isolates sharing almost a quarter of its genome. The participation of phages in introgression events and consequent impact on host ecology and evolution remain elusive. Three distinct prophages, named C. j...

Diagnosis of Helicobacter pylori infection

Several studies addressed the usefulness of using molecular techniques for the diagnosis of Helicobacter pylori, pointing to the emerging paradigm change for clinical microbiology laboratories. During the last year, new variations of PCR-based approaches (formats, probes), new targets, as well as non-PCR based methods were described. In most cases, molecular methods combine detection of H. pylori with antimicro...

Liposomal Delivery of Newly Identified Prophage Lysins in a Pseudomonas aerugin...

Pseudomonas aeruginosa is a Gram-negative opportunistic bacterium that presents resistance to several antibiotics, thus, representing a major threat to human and animal health. Phage-derived products, namely lysins, or peptidoglycan-hydrolyzing enzymes, can be an effective weapon against antibiotic-resistant bacteria. Whereas in Gram-positive bacteria, lysis from without is facilitated by the exposed peptidogly...

Repeated out-of-Africa expansions of Helicobacter pylori driven by replacement ...

Helicobacter pylori lives in the human stomach and has a population structure resembling that of its host. However, H. pylori from Europe and the Middle East trace substantially more ancestry from modern African populations than the humans that carry them. Here, we use a collection of Afro-Eurasian H. pylori genomes to show that this African ancestry is due to at least three distinct admixture events. H. pylori...