53 documents found, page 1 of 6
Brain-derived neurotrophic factor modulation in response to oxidative stress an...
Correia, Ana Salomé; Torrado, Marília; Costa-Coelho, Tiago; Carvalho, Eva Daniela; Inteiro-Oliveira, Sara; Diógenes, Maria José; Pêgo, Ana PaulaMajor Depressive Disorder (MDD) is a very complex disease, challenging to study and manage. The complexities of MDD require extensive research of its mechanisms to develop more effective therapeutic approaches. Crucial in the context of this disease is the role of brain-derived neurotrophic factor (BDNF) signaling pathway. Aim: This manuscript aims to explore the complex relationship between MDD and BDNF signal...
Chlamydial and Gonococcal Genital Infections: A Narrative Review
Rodrigues, Rafaela; Vieira-Baptista, Pedro; Catalão, Carlos; Borrego, Maria José; Sousa, Carlos; Vale, NunoSexually transmitted infections (STIs) constitute one of the leading causes of disease burden worldwide, leading to considerable morbidity, mortality, health expenditures, and stigma. Of note are the most common bacterial STIs, chlamydial and gonococcal infections, whose etiological agents are Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG), respectively. Despite being usually asymptomatic, in some ca...
Prediction of CYP-Mediated Drug Interaction Using Physiologically Based Pharmac...
Marques, Lara; Vale, NunoDrug-drug interactions (DDIs) represent a significant concern in healthcare, particularly for patients undergoing polytherapy. DDIs can lead to a range of outcomes, from decreased therapeutic effectiveness to adverse effects. Salbutamol, a bronchodilator recommended for the treatment of respiratory diseases, is metabolized by cytochrome P450 (CYP) enzymes, which can be inhibited or induced by co-administered dr...
Improvement of the in vitro cytotoxic effect on HT-29 colon cancer cells by com...
Falcão, Soraia; Duarte, Diana; Diallo, Moustapha; Santos, Joana B.; Ribeiro, Eduarda; Vale, Nuno; Vilas-Boas, MiguelCancer is regard as one of the key factors of mortality and morbidity in the world. Treatment is mainly based on chemotherapeutic drugs that, when used in targeted therapies, have serious side effects. 5-fluorouracil (5-FU) is a drug commonly used against colorectal cancer (CRC), despite its side effects. Combination of this compound with natural products is a promising source in cancer treatment research. In r...
The effects of chitosan on the healing process of oral mucosa: an observational...
Jesus, Gonçalo de; Marques, Lara; Vale, Nuno; Mendes, Rui AmaralThe healing process is a dynamic process accompanied by some classical symptoms of inflammation such as redness, swelling, pain, and loss of function. Chitosan is a natural polymer with properties that contribute to tissue healing, with properties that could be applied in periodontal therapy, such as the wound healing of oral mucosa. This experimental split-mouth study aims to assess the possibilities of chitos...
Sporopollenin-based bio-microcapsules as green carriers for controlled delivery...
Aylanc, Volkan; Peixoto, Andreia F.; Vale, Nuno; Freire, Cristina; Vilas-Boas, MiguelThe production and design of innovative in-body microcarrier platforms for the controlled delivery of bioactive substances to predefined sites continue to hold substantial promise for biotechnology and medicine by increasing their therapeutic benefits. In this scope, plant pollen-based biocapsules, sporopollenin structures, have emerged as an alternative to synthetic ones due to their low-cost, highly uniform s...
Honeybee venom synergistically enhances the cytotoxic effect of CNS drugs IN HT...
Duarte, Diana; Falcão, Soraia; El Mehdi, Iouraouine; Vilas-Boas, Miguel; Vale, Nuno5-fluorouracil (5-FU) and doxorubicin (DOX) are potent anti-tumour agents commonly used for colon and breast cancer therapy, respectively. However, their clinical application is limited by their side effects and the development of drug resistance. Honeybee venom is a complex mixture of substances that has been reported to be effective against different cancer cells. Its active compound is melittin, a positively...
Cell Model of Depression: Reduction of Cell Stress with Mirtazapine
Correia, Ana Salomé; Fraga, Sónia; Teixeira, João Paulo; Vale, NunoDepression is a very prevalent and complex disease. This condition is associated with a high rate of relapse, making its treatment a challenge. Thus, an intensive investigation of this disease and its treatment is necessary. In this work, through cell viability assays (MTT and neutral red assays) and alkaline comet assays, we aimed to test the induction of stress in human SH-SY5Y cells through the application o...
New Peptide Functionalized Nanostructured Lipid Carriers with CNS Drugs and Eva...
Silva, Sara; Marto, Joana; Gonçalves, Lídia; Duarte, Diana; Soares, Olívia Salomé G. P.; Vasques-Nóvoa, Francisco; Almeida, António J.; Vale, NunoNanoparticulate systems have been widely investigated as delivery vectors for efficient drug delivery in different diseases. Nanostructured lipid carriers (NLC) are composed of both solid and liquid lipids (glyceryl dibehenate and diethylene glycol monoethyl ether) and have demonstrated enhanced biological compatibility and increased drug loading capability. Furthermore, the use of peptides, in particular cell-...
Development of Neuropeptide Y and Cell-Penetrating Peptide MAP Adsorbed onto Li...
Silva, Sara; Marto, Joana; Gonçalves, Lídia; Fernandes, Henrique S.; Sousa, Sérgio F.; Almeida, António José; Vale, NunoFunctionalization of nanoparticles surfaces have been widely used to improve diagnostic and therapeutic biological outcome. Several methods can be applied to modify nanoparticle surface; however, in this article we focus toward a simple and less time-consuming method. We applied an adsorption method on already formulated nanostructured lipid carriers (NLC) to functionalize these nanoparticles with three distinc...