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Enhanced LTP in aged rats: detrimental or compensatory?

Pinho, Júlia; Vale, Ruben; Batalha, Vânia; Costenla, Ana Rita; Dias, Raquel Baptista; Rombo, Diogo M.; Sebastião, Ana M; De Mendonça, Alexandre

Age-dependent memory deterioration has been well documented and yet an increase in rat hippocampal LTP upon aging has been reported. This poses the question of whether the enhanced LTP is a cause or an attempt to compensate the memory deficits described in aged rats. Hippocampal slices from young, adult and aged Wistar rats were pre-incubated, with an NMDA receptor (NMDAR) antagonist, memantine (1 μM, 4 h), and...

Date: 2017   |   Origin: Repositório da Universidade de Lisboa
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