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The Influence of CYP3A4 Polymorphism in Sex Steroids as a Risk Factor for Breas...

Veiga,Melissa Gonzalez; Felizi,Rogério Tadeu; Reis,Dayane Guerino; Carelli Filho,Ivo; Fernandes,Cesar Eduardo; Souto,Ricardo Peres do; Oliveira,Emerson

Abstract Objective Epidemiological studies have shown evidence of the effect of sex hormones in the pathogenesis of breast cancer, and have suggested a relationship of the disease with variations in genes involved in estrogen synthesis and/or metabolism. The aim of the present study was to evaluate the association between the CYP3A4*1B gene polymorphism (rs2740574) and the risk of developing breast cancer. Meth...

Date: 2018   |   Origin: Oasisbr
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