8 documents found, page 1 of 1
FoxP3, GATA-3 and T-bet expression in elderly asthma
Vale-Pereira, S; Todo-Bom, A; Geraldes, L; Schmidt-Weber, C; Akdis, CA; Mota-Pinto, ABACKGROUND: Asthma is a chronic inflammatory disorder in which Th2, Th1 and suppressive T cells (Tregs) play a role. The transcription factor FoxP3 plays a role in Treg differentiation while T-bet is important for Th1 and GATA-3 for Th2 differentiation from naïve T cells. Recent data show that age-related deregulation of Treg cells is a mechanism of senescence affecting several chronic diseases. It is crucial t...
Asma: Reflexo da apoptose e de fenótipos de regulação
Todo-Bom, A; Mota-Pinto, A; Alves, V; Vale-Pereira, S; Chieira, S; Santos-Rosa, MA asma é uma doença inflamatória crónica das vias aéreas, e os linfócitos T desempenham um papel central na sua patogénese. Na inflamação alérgica quer os eosinófilos quer os linfócitos T podem ter um tempo de vida aumentado no local da inflamação, por redução da apoptose, mantendo-se activados. No pulmão encontra-se uma subclasse de linfócitos T que expressa receptor γδ. Estes linfócitos T γδ (TCRγδ) represent...
Apoptosis and asthma in the elderly
Todo-Bom, A; Mota-Pinto, A; Alves, V; Vale-Pereira, S; Santos-Rosa, MBACKGROUND: Asthma is a chronic inflammatory disorder of the airways. The persistence of airway inflammation depends on a decrease in apoptosis of T lymphocytes and eosinophils and survival of these activated cells. T lymphocytes expressing gamma delta receptors can be identified in human lungs and play an important role in immune defence against pathogens and in the regulation of chronic inflammation. Aging is...
Elevated neopterin levels in non-allergic asthma
Mota-Pinto, A; Todo-Bom, A; Vale-Pereira, S; Alves, V; Santos-Rosa, MNeopterin is synthesized by human monocyte-derived macrophages upon stimulation with interferon-gamma (IFN-gamma). Measurement of neopterin concentration is useful to monitor cell-mediated (Th1-type) immune activation. In this study, we aimed to analyze the behaviour of neopterin in long lasting asthma considering its role as a marker of the Th1 environment and to establish the distinction between patients belo...
Substância P na asma brônquica: Intervenção nos mecanismos de oxidação e activa...
Todo-Bom, A; Mota-Pinto, A; Vale-Pereira, S; Alves, V; Dourado, M; Chieira, C; Santos-Rosa, MThe substance P (SP) was described in the beginning of the XXth Century, and its biological actions was recognized to have implications in neurogenic inflammation and constriction of smooth muscles. The bronchial asthma prevalence has been increasing in all developed countries. The changes associated to inflammatory chronicity can compromise the organ function reversibility. The role of neuromechanisms in the p...
Substance P in Long-Lasting Asthma: Immunoinflammatory pathways
Todo-Bom, A; Mota-Pinto, A; Vale-Pereira, S; Alves, V; Dourado, M; Santos-Rosa, MBackground: Substance P (SP) was described at the beginning of the 20th Century, and its biological action was recognized to have implications in neurogenic inflammation and constriction of smooth muscles. The changes associated with inflammatory chronicity can compromise organ function reversibility. The role of neuromechanisms in the pathology of the disease has been investigated in order to achieve better di...
Determinação da neopterina e de defesas antioxidantes na asma de evolução arras...
Mota-Pinto, A; Todo-Bom, A; Vale-Pereira, S; Alves, V; Santos-Rosa, MAsthma is a condition characterised by a chronic immunoinflammatory response to different triggers. Neopterin (NPT) is synthesised by human macrophages upon stimulation with interferon-gamma and is also capable of enhancing the oxidative potential of reactive oxygen species. NPT is useful for the monitoring of cell-mediated (Th1-type) immune activation. This study analysed the behaviour of NPT in long lasting a...
Doseamento das granzimas A e B na sarcoidose pulmonar (estudo experimental)
Dourado, M; Bento, J; Mesquita, L; Marques, A; Vale-Pereira, S; Ribeiro, AB; Mota-Pinto, ASarcoidosis is a systemic disease of unknown aetiology, morphologically characterized by well-formed epithelioid granulomas, which show little or no central necrosis. These may be present in any organ or tissue. The lung is the most frequently and prominently involved target. The granuloma is often very sharply demarcated from the adjacent tissue and is surrounded by a mantle of lymphocytes, which mediate lysis...