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Unveiling Antibiotic Resistance, Clonal Diversity, and Biofilm Formation in Iso...
Silva, Adriana; Silva, Vanessa; Dapkevicius, Maria de Lurdes Enes; Azevedo, Mónica; Cordeiro, Rui; Pereira, José Eduardo; Valentão, PatríciaEscherichia coli, a commensal microorganism found in the gastrointestinal tract of human and animal hosts, plays a central role in agriculture and public health. Global demand for animal products has promoted increased pig farming, leading to growing concerns about the prevalence of antibiotic-resistant E. coli strains in swine populations. It should be noted that a significant portion of antibiotics deployed i...
The role of ayahuasca in cell viability and oxidative stress in gastric adenoca...
Gonçalves, Joana; Cascalheira, José; Valentão, Patrícia; Luís, Ângelo; Gallardo, Eugenia; Duarte, Ana PaulaAyahuasca, a psychoactive beverage native to the Amazon, originally derived from Banisteriopsis caapi stem scrapings and Psychotria viridis leaves, exhibits hallucinogenic properties due to N,Ndimethyltryptamine. When combined with β-carbolines, it enters the bloodstream and central nervous system, inhibiting monoamine oxidase-A. Over time, therapeutic effects have been associated to ayahuasca consumption. This...
Fisetin derivatives exhibit enhanced anti-inflammatory activity and modulation ...
Silva, Daniela Correia da; Jervis, Peter John; Martins, J. A. R.; Valentão, Patrícia; Ferreira, Paula M. T.; Pereira, David M.Fisetin (FST) is a dietary flavonol that is known to possess multiple relevant bioactivities, raising the question of its potential health benefits and even its use in novel pharmacological approaches. To attain this prospect, some limitations to this molecule, namely its poor bioavailability and solubility, must be addressed. Inflammation and endoplasmic reticulum (ER) stress are often hand in hand in the cont...
Seaweed as a natural source against phytopathogenic bacteria
Vicente, Tânia F.L.; Félix, Carina; Félix, Rafael; Valentão, Patrícia; Lemos, Marco F.L.Plant bacterial pathogens can be devastating and compromise entire crops of fruit and vegetables worldwide. The consequences of bacterial plant infections represent not only relevant economical losses, but also the reduction of food availability. Synthetic bactericides have been the most used tool to control bacterial diseases, representing an expensive investment for the producers, since cyclic applications ar...
Red seaweed-derived compounds as a potential new approach for acne vulgaris care
Januário, Adriana P.; Félix, Rafael; Félix, Carina; Reboleira, João; Valentão, Patrícia; Lemos, Marco F.L.Acne vulgaris (AV) is a chronic skin disease of the pilosebaceous unit affecting both adolescents and adults. Its pathophysiology includes processes of inflammation, increased keratinization, sebum production, hormonal dysregulation, and bacterial Cutibacterium acnes proliferation. Common AV has been treated with antibiotics since the 1960s, but strain resistance has emerged and is of paramount concern. Macroal...
Marine macroalgae, a source of natural inhibitors of Fungal Phytopathogens
Vicente, Tânia F. L.; Lemos, Marco F.L.; Valentão, Patrícia; Félix, Rafael; Félix, CarinaFungal phytopathogens are a growing problem all over the world; their propagation causes significant crop losses, affecting the quality of fruits and vegetables, diminishing the availability of food, leading to the loss of billions of euros every year. To control fungal diseases, the use of synthetic chemical fungicides is widely applied; these substances are, however, environmentally damaging. Marine algae, on...
Biological evaluation of naproxen–dehydrodipeptide conjugates with self-hydroge...
Moreira, Rute; Jervis, Peter John; Carvalho, André; Ferreira, Paula M. T.; Martins, J. A. R.; Valentão, Patrícia; Andrade, Paula B.; Pereira, David M.The use of peptide–drug conjugates is emerging as a powerful strategy for targeted drug delivery. Previously, we have found that peptides conjugated to a non-steroidal anti-inflammatory drug (NSAID), more specifically naproxen–dehydrodipeptide conjugates, readily form nanostructured fibrilar supramolecular hydrogels. These hydrogels were revealed as efficacious nano-carriers for drug delivery applications. More...
Evaluating the in vitro potential of natural extracts to protect lipids from ox...
Félix, Rafael; Valentão, Patrícia; Andrade, Paula B.; Félix, Carina; Novais, Sara C.; Lemos, Marco F.L.Lipid peroxidation is a chemical reaction known to have negative impacts on living organisms’ health and on consumer products’ quality and safety. Therefore, it has been the subject of extensive scientific research concerning the possibilities to reduce it, both in vivo and in nonliving organic matrices. It can be started by a variety of oxidants, by both ROS-dependent and -independent pathways, all of them rev...
Magnetic dehydrodipeptide-based self-assembled hydrogels for theragnostic appli...
Carvalho, André; Gallo, Juan; Pereira, David M.; Valentão, Patrícia; Andrade, Paula B.; Hilliou, L.; Ferreira, Paula M. T.; Bañobre-López, ManuelSelf-assembled peptide hydrogels have emerged in recent years as the new paradigm in biomaterials research. We have contributed to this field the development of hydrogels based on dehydrodipeptides <i>N</i>-capped with naproxen. The dehydrodipeptide hydrogels can be loaded with drugs, thus being potential nanocarriers for drug delivery. In this work novel dehydrodipeptides containing tyrosine and aspartic acid ...
Host-defense peptides AC12, DK16 and RC11 with immunomodulatory activity isolat...
Popov, Cláudia S. F. C.; Magalhães, Beatriz Simas; Goodfellow, Brian James; Bocca, Anamélia Lorenzetti; Pereira, David M.; Andrade, Paula B.Inflammation is a natural defense mechanism of the immune system; however, when unregulated, it can lead to chronic illness. Glucocorticoids are the most commonly used agents to effectively treat inflammatory conditions, including autoimmune diseases, however these substances can trigger a number of side effects. Thus, viable alternatives to the use of these drugs would be advantageous. In this study, we have a...