3 documents found, page 1 of 1
Advanced face mask filters based on PCL electrospun meshes dopped with antimicr...
Ferreira, Carolina A. M.; Guerreiro, Sara F.C.; Valente, Joana F. A.; Patrício, Tatiana M.F.; Alves, Nuno; Mateus, Artur; Dias, Juliana R.The pandemic situation caused by coronavirus clearly demonstrated the need for alternatives able to protect the respiratory tract and inactivate the infectious agents. Based on this, antibacterial face-mask filters of polycaprolactone (PCL) dopped with magnesium oxide (MgO) and copper oxide (CuO) nanoparticles (NPs) were produced using an electrospinning technique. A morphological analysis of electrospun meshes...
p53 as the Focus of Gene Therapy: Past, Present and Future
Valente, Joana F. A.; Queiroz, João; Sousa, FaniBackground: Several gene deviations can be responsible for triggering oncogenic processes. However, mutations in tumour suppressor genes are usually more associated to malignant diseases, with p53 being one of the most affected and studied element. p53 is implicated in a number of known cellular functions, including DNA damage repair, cell cycle arrest in G1/S and G2/M and apoptosis, being an interesting target...
Poly(ester amide)s based on (L)-lactic acid oligomers and α-amino acids: influe...
Fonseca, Ana C; Coelho, Jorge F. J.; Valente, Joana F. A.; Correia, Tiago R.; Correia, Ilídio J.; Gil, Maria H.; Simões, Pedro N.Novel biodegradable and low cytotoxic poly(ester amide)s (PEAs) based on α-amino acids and (L)-lactic acid (L-LA) oligomers were successfully synthesized by interfacial polymerization. The chemical structure of the new polymers was confirmed by spectroscopic analyses. Further characterization suggests that the α-amino acid plays a critical role on the final properties of the PEA. L-phenylalanine provides PEAs w...