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Brain Hemispheric Asymmetry in Schizophrenia and Bipolar Disorder

Pinto, Diogo; Martins, Ricardo; Macedo, António; Castelo-Branco, Miguel; Valente Duarte, João; Madeira, Nuno

Background: This study aimed to compare brain asymmetry in patients with schizophrenia (SCZ), bipolar disorder (BPD), and healthy controls to test whether asymmetry patterns could discriminate and set boundaries between two partially overlapping severe mental disorders. Methods: We applied a fully automated voxel-based morphometry (VBM) approach to assess structural brain hemispheric asymmetry in magnetic reson...


A Fundamental Distinction in Early Neural Processing of Implicit Social Interpr...

Madeira, Nuno; Martins, Ricardo Filipe Alves; Valente Duarte, João; Costa, Gabriel Nascimento Ferreira da; Macedo, António Ferreira de

Background: Social cognition impairment is a key phenomenon in serious mental disorders such as schizophrenia (SCZ) and bipolar disorder (BPD). Although genetic and neurobiological studies have suggested common neural correlates, here we hypothesized that a fundamental dissociation of social processing occurs at an early level in these conditions. Methods: Based on the hypothesis that key structures in the soci...


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