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Inhalation of the prodrug PI3K inhibitor CL27cimproves lung function in asthma ...
Campa, Carlo C.; Silva, Rangel L.; Margaria, Jean P.; Piral, Tracey; Mattos, Matheus S.; Kraemer, Lucas R.; Reis, Diego C.; Grosa, GiorgioPI3K activation plays a central role in the development of pulmonary inflammation and tissue remodeling. PI3K inhibitors may thus offer an improved therapeutic opportunity to treat non-resolving lung inflammation but their action is limited by unwanted on-target systemic toxicity. Here we present CL27c, a prodrug pan-PI3K inhibitor designed for local therapy, and investigate whether inhaled CL27c is effective i...
Data: 2019
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Origem: Oasisbr