11 documents found, page 1 of 2

Health literacy – study protocol for LiSa cohort study

Background: Health literacy is the degree to which individuals have the ability to find, understand, and use information and services to inform health-related decisions and actions for themselves and others, whether at home, at the workplace, in the community, marketplace, healthcare sector, or the political arena. The main aim of this project is to measure health literacy in the adult population living in the ...

Anti-algics in the therapeutic response of breast and urological cancers

The effect of anti-algics on tumor progression and the overall survival of patients is controversial and remains unclear. Herein, we disclose the in vitro effects of the local anesthetics lidocaine, ropivacaine, and levobupivacaine on breast (MCF7), prostate (PC3, LNCaP), and bladder (TCCSUP, HT1376) cancer cell lines, both as monotherapy and in combination with standard-of-care therapeutics. Assays for cell pr...

The Potential Effect of Lidocaine, Ropivacaine, Levobupivacaine and Morphine on...

Breast cancer (BC) is one of the most common types of cancer and the second leading cause of death in women. Local anaesthetics (LAs) and opioids have been shown to influence cancer progression and metastasis formation in several pre-clinical studies. However, their effects do not seem to promote consensus. A systematic review was conducted using the databases Medline (via PubMed), Scopus, and Web of Science (2...

Rocurónio ou Succinilcolina na Intubação de Sequência Rápida: resultados de um ...

Introdução: A succinilcolina tem sido o pilar da Intubação de Sequência Rápida (ISR) há mais de 50 anos, mas o rocurónio tem surgido como uma alternativa válida. Este estudo teve como objectivo avaliar o uso de relaxantes musculares (RM) na ISR entre os anestesiologistas portugueses. Material e Métodos: Um questionário electrónico anónimo com 16 questões foi enviado para 596 anestesiologistas portugueses por em...

Ketamine alone or combined with midazolam or dexmedetomidine does not affect an...

Ketamine administration has been associated with controversial behavioural impairments and psychotic episodes. Even though ketamine alone and in combination with midazolam or dexmedetomidine are frequently used in laboratory animals, the side-effects of such protocols are not well known. Therefore, our aim was to evaluate the effects of ketamine alone and in combination with midazolam or dexmedetomidine on emot...

A single intraperitoneal injection of ketamine does not affect spatial working ...

CONTEXT: Ketamine is an anaesthetic and analgesic drug used in research and clinical practice. Little is known about the effects of different doses of this drug on memory and brain cellular death. OBJECTIVE: To study the effects of different doses of ketamine on working and reference memory, and neurodegeneration in adult mice. DESIGN: A randomised study. SETTINGS: The study was carried out in a basic science l...

Apoptotic neurodegeneration and spatial memory are not affected by sedative and...

Background. Ketamine is increasingly popular in clinical practice and its combination with a 2-agonists can provide good anaesthetic stability. Little is known about the effects of this combination in the brain. Therefore, we investigated the effects of different concentrations of ketamine combined with medetomidine on cognition and its potential apoptotic neurodegenerative effect in adult mice. Methods. Sevent...

Different Concentrations of Ketamine did not Affect Cognition or Neurodegenerat...

Background: Ketamine is used in clinic how anesthetic and analgesic agent (1). However, little is known about the effects of the acute administration of this drug in brain of adult mice. The aim of this work was to study the effect of different concentrations of ketamine on cognition and its neurodegenerative effects. Methods: Forty-eight mice males, inbred C57BL/6, with 28 weeks old, were divided into 4 differ...

Cognitive and neurodegenerative effects of the ketamine/medetomidine anesthesia...

Cognitive and Neurodegenerative Effects of the Medetomidine/Ketamine Anesthesia...

Background: Medetomidine (MED)/Ketamine (KET) is a commonly used combination in laboratory animals. Several studies have shown that KET can enhance neuronal death in neonates (1). Nerveless, little is known about its effect in combination with Med and in adult. The aim of this work was to study the effect of different concentrations of MED/KET in cognition and its potential neurodegenerative effect in adult mic...