2 documents found, page 1 of 1
Hydrazones in anion transporters: the detrimental effect of a second binding site
Martínez-Crespo, Luis; Halgreen, Lau; Soares, Márcio; Marques, Igor; Félix, Vítor; Valkenier, HennieSynthetic anion transporters can be developed using anion receptors that are able to bind the anion and stabilize it in the lipophilic interior of a bilayer membrane, and they usually contain functional groups with acidic NHs, such as ureas, thioureas and squaramides. To assess the suitability of acylhydrazones as a new functional group for the preparation of anion transporters, we have studied a family of thio...
Tilting and Tumbling in Transmembrane Anion Carriers: Activity Tuning through n...
Edwards, Sophie J.; Marques, Igor; Dias, Christopher M.; Tromans, Robert A.; Lees, Nicholas R.; Felix, Vitor; Valkenier, Hennie; Davis, Anthony P.Anion transport by synthetic carriers (anionophores) holds promise for medical applications, especially the treatment of cystic fibrosis. Among the factors which determine carrier activity, the size and disposition of alkyl groups is proving remarkably important. Herein we describe a series of dithioureidodecalin anionophores, in which alkyl substituents on one face are varied from C-0 to C-10 in two-carbon ste...