3 documents found, page 1 of 1
Chemical composition and biological properties of Ipomoea procumbens
Batiga,Saadia; Valli,Marilia; Zeraik,Maria L.; Fraige,Karina; Leme,Gabriel M.; Pitangui,Nayla S.; Almeida,Ana Marisa F.; Michel,SylvieABSTRACT Natural products have been the most valuable source of chemical compounds in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. Brazil has an exceptionally rich biodiversity, and a valuab...
Synthetic Analogue of the Natural Product Piperlongumine as a Potent Inhibitor ...
Valli,Marilia; Altei,Wanessa; Santos,Ricardo N. dos; Lucca Jr.,Emilio C. de; Dessoy,Marco A.; Pioli,Renan M.; Cotinguiba,Fernando; Cachet,XavierPiperlongumine is a natural amide alkaloid isolated from several species of Piper and is described in the literature as selectively cytotoxic to several cancer cell lines. Inhibiting cell migration has gained considerable interest as an approach for discovering antimetastatic agents because this process is fundamental to metastasis. Piperlongumine, selected from cell-based assay screening of NuBBE Database, inh...
Tropical biodiversity: has it been a potential source of secondary metabolites ...
Valli,Marilia; Pivatto,Marcos; Danuello,Amanda; Castro-Gamboa,Ian; Silva,Dulce Helena Siqueira; Cavalheiro,Alberto José; Araújo,Ângela ReginaThe use of natural products has definitely been the most successful strategy in the discovery of novel medicines. Secondary metabolites from terrestrial and marine organisms have found considerable use in the treatment of numerous diseases and have been considered lead molecules both in their natural form and as templates for medicinal chemistry. This paper seeks to show the great value of secondary metabolites...