4 documents found, page 1 of 1
Quetiapine treatment reverses depressive-like behavior and reduces DNA methyltr...
Ignácio, Zuleide M.; Réus, Gislaine Z.; Abelaira, Helena M.; Maciel, Amanda L.; Moura, Airam B. de; Matos, Danyela; Demo, Júlia P.Stress in early life has been appointed as an important phenomenon in the onset of depression and poor response to treatment with classical antidepressants. Furthermore, childhood trauma triggers epigenetic changes, which are associated with the pathophysiology of major depressive disorder (MDD). Treat- ment with atypical antipsychotics such as quetiapine, exerts therapeutic effect for MDD patients and induces ...
The effects of histone deacetylase inhibition on the levels of cerebral cytokin...
Valvassori, Samira S.; Resende, Wilson R.; Varela, Roger B.; Arent, Camila O.; Gava, Fernanda F.; Peterle, Bruna R.; Dal-Pont, Gustavo C.Studies have suggested the involvement of inflamma- tory processes in the physiopathology of bipolar disorder. Preclinical evidences have shown that histone deacetylase inhib- itors may act as mood-stabilizing agents and protect the brain in models of mania and depression. The aim of the present study was to evaluate the effects of sodium butyrate (SB) and valproate (VPA) on behavioral changes, histone deacetyl...
Lithium ameliorates sleep deprivation-induced mania-like behavior, hypothalamic...
Valvassori, Samira S.; Resende, Wilson R.; Dal-Pont, Gustavo; Sangaletti-Pereira, Heron; Gava, Fernanda F.; Peterle, Bruna R.; Carvalho, André F.Objectives: The goal of the present study was to investigate the effects of lithium administration on behavior, oxidative stress parameters and cytokine levels in the periphery and brain of mice subjected to an animal model of mania induced by paradoxical sleep deprivation (PSD). Methods: Male C57 mice were treated with saline or lithium for 7 days. The sleep deprivation protocol started on the 5th day during f...
Decreased BDNF levels in amygdala and hippocampus after intracerebroventricular...
Jornada, Luciano K.; Valvassori, Samira S.; Resende, Wilson R.; Moretti, Morgana; Ferreira, Camila L.; Fries, Gabriel R.; Kapczinski, FlavioOBJECTIVE: The present study aims to investigate the effects of ouabain intracerebroventricular injection on BDNF levels in the amygdala and hippocampus of Wistar rats. METHODS: Animals received a single intracerebroventricular injection of ouabain (10-3 and 10-2 M) or artificial cerebrospinal fluid and immediately, 1h, 24h, or seven days after injection, BDNF levels were measured in the rat's amygdala and hipp...