2 documents found, page 1 of 1
Extracellular Alpha-Synuclein Oligomers Modulate Synaptic Transmission and Impa...
Diógenes, Maria José; Dias, Raquel B.; Rombo, Diogo M.; Miranda, Hugo Vicente; Maiolino, Francesca; Guerreiro, Patrícia; Näsström, ThomasParkinson’s disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of -synuclein (a-syn) in various brain regions is themajorpathological hallmark. Indeed, themotorsymptomsinPDare causedby a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of the brain. In a...
Extracellular alpha-synuclein oligomers modulate synaptic transmission and impa...
Diógenes, Maria José; Dias, Raquel Baptista; Rombo, Diogo M.; Vicente Miranda, Hugo; Maiolino, Francesca; Guerreiro, Patrícia; Nasstrom, ThomasParkinson's disease (PD) is the most common representative of a group of disorders known as synucleinopathies, in which misfolding and aggregation of α-synuclein (a-syn) in various brain regions is the major pathological hallmark. Indeed, the motor symptoms in PD are caused by a heterogeneous degeneration of brain neurons not only in substantia nigra pars compacta but also in other extrastriatal areas of the br...