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3-Hydroxypyrrolidine and (3,4)-dihydroxypyrrolidine derivatives: inhibition of ...
Carreiro, E. P.; Louro, P.; Adriano, G; Guedes, R. A.; Vannuchic, N.; Costa, A. R.; Antunes, C. M.; Guedes, R. C.; Burke, A.J.Thirteen pyrrolidine-based iminosugar derivatives have been synthesized and evaluated for inhibition of α-glucosidase from rat intestine. The compounds studied were the non-hydroxy, mono-hydroxy and dihydroxypyrrolidines. All the compounds were N-benzylated apart from one. Four of the compounds had a carbonyl group in the 2,5-position of the pyrrolidine ring. The most promising iminosugar was the trans-3,4-dihy...
Date: 2015
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Origin: Repositório Científico da Universidade de Évora