2 documents found, page 1 of 1
Can bystander effects of metals in Daphnia magna be mediated by DNA methylation?
Jeremias, Guilherme; Lourenço, Joana; Araujo, Cristiano V. M.; Van Nieuwerburgh, Filip; Gonçalves, Fernando J. M.; Asselman, Jana; Pereira, Joana L.The bystander phenomenon can be described as the detection of effects in non-exposed cells/individuals when these come in contact with exposed ones. Bystander literature has focused mostly on the detection of effects rather than understanding the underlying mechanisms, thus these remain largely unknown from a molecular perspective. Epigenetic mechanisms play a major role in biological responses to environmental...
Analysis of shared heritability in common disorders of the brain
Anttila, Verneri; Bulik-Sullivan, Brendan; Finucane, Hilary K.; Walters, Raymond K.; Bras, Jose; Duncan, Laramie; Escott-Price, ValentinaDisorders of the brain can exhibit considerable epidemiological comorbidity and often share symptoms, provoking debate about their etiologic overlap. We quantified the genetic sharing of 25 brain disorders from genome-wide association studies of 265,218 patients and 784,643 control participants and assessed their relationship to 17 phenotypes from 1,191,588 individuals. Psychiatric disorders share common varian...