7 documents found, page 1 of 1
Analysis of mutational history of multidrug‐ resistant genotypes with a mutagen...
Abecasis, AB; Vandamme, AM; the EuResist Network Study GroupHuman immunodeficiency virus (HIV) can develop resistance to all antiretroviral drugs. Multidrug resistance, however, is a rare event in modern HIV treatment, but can be life‐threatening, particular in patients with very long therapy histories and in areas with limited access to novel drugs. To understand the evolution of multidrug resistance, we analyzed the EuResist database to uncover the accumulation of mut...
Increasing prevalence of HIV-1 transmitted drug resistance in Portugal
Pingarilho, Marta; Pimentel, Victor; Diogo, Isabel; Fernandes, Sandra; Miranda, Mafalda; Pineda-Peña, AC; Libin, Pieter; Theys, Kristof; Martins, MRIntroduction: Treatment for All recommendations have allowed access to antiretroviral (ARV) treatment for an increasing number of patients. This minimizes the transmission of infection but can potentiate the risk of transmitted (TDR) and acquired drug resistance (ADR). Objective: To study the trends of TDR and ADR in patients followed up in Portuguese hospitals between 2001 and 2017. Methods: In total, 11,911 p...
Earlier initiation of antiretroviral treatment coincides with an initial contro...
Vinken, Lore; Katrien, Fransen,; Cuypers, Lize; Alexiev, Ivailo; Balotta, Claudia; Laurent, Debaisieux,; Carole, Seguin-Devaux,; Sergio Garcìa, Ribas,Human immunodeficiency virus type 1 (HIV-1) non-B subtype infections occurred in Belgium since the 1980s, mainly amongst migrants and heterosexuals, whereas subtype B predominated in men-having-sex-with-men (MSM). In the last decade, the diagnosis of F1 sub-subtype in particular has increased substantially, which prompted us to perform a detailed reconstruction of its epidemiological history. To this purpose, t...
A computational method for the identification of dengue, zika and chikungunya v...
Fonseca, Vagner S.; Libin, Pieter J. K.; Theys, Kristof; Faria, Nuno Rodrigues; Nunes, Márcio Roberto Texeira; Restovic, Maria I.; Freire, MuriloIn recent years, an increasing number of outbreaks of Dengue, Chikungunya and Zika viruses have been reported in Asia and the Americas. Monitoring virus genotype diversity is crucial to understand the emergence and spread of outbreaks, both aspects that are vital to develop effective prevention and treatment strategies. Hence, we developed an efficient method to classify virus sequences with respect to their sp...
Time to harmonize dengue nomenclature and classification
Cuypers, Lize; Pieter J.K., Libin,; Peter, Simmonds,; Nowé, Ann; Jorge Luis, Muñoz-Jordán,; Luiz Carlos, Júnior Alcântara,; Vandamme, AMDengue virus (DENV) is estimated to cause 390 million infections per year worldwide. A quarter of these infections manifest clinically and are associated with a morbidity and mortality that put a significant burden on the affected regions. Reports of increased frequency, intensity, and extended geographical range of outbreaks highlight the virus's ongoing global spread. Persistent transmission in endemic areas ...
Expert consensus statement on the science of HIV in the context of criminal law
F., Barré-Sinoussi,; S. S., Abdool Karim,; Albert , J,; L., Bekker,; C., Beyrer,; P., Cahn,; A., Calmy,; B., Grinsztejn,; Grulich, A.; A., Kamarulzaman,INTRODUCTION: Globally, prosecutions for non-disclosure, exposure or transmission of HIV frequently relate to sexual activity, biting, or spitting. This includes instances in which no harm was intended, HIV transmission did not occur, and HIV transmission was extremely unlikely or not possible. This suggests prosecutions are not always guided by the best available scientific and medical evidence. DISCUSSION: Tw...
CRF19_cpx is an evolutionary fit HIV-1 variant exclusively associated with rapi...
Kourí, Vivian; Khouri, Ricardo; Alemán, Yoan; Vercauteren, Jurgen; Pineda-Peña, AC; Theys, Kristof; Megens, S.; Moutschen, M.; Pfeifer, NicoBACKGROUND: Clinicians reported an increasing trend of rapid progression (RP) (AIDS within 3 years of infection) in Cuba. METHODS: Recently infected patients were prospectively sampled, 52 RP at AIDS diagnosis (AIDS-RP) and 21 without AIDS in the same time frame (non-AIDS). 22 patients were sampled at AIDS diagnosis (chronic-AIDS) retrospectively assessed as > 3 years infected. Clinical, demographic, virologica...