4 documents found, page 1 of 1
Evaluation of mutagenicity and metabolism-mediated cytotoxicity of the naphthoq...
Kitagawa,Rodrigo R.; Vilegas,Wagner; Varanda,Eliana A.; Raddi,Maria S.G.A large number of quinones have been associated with antitumor, antibacterial, antimalarial, and antifungal activities. Results of previous studies of 5-methoxy-3,4-dehydroxanthomegnin, a naphthoquinone isolated fromPaepalanthus latipes Silveira, Eriocaulaceae, revealed antitumor, antibacterial, immunomodulatory, and antioxidant activities. In this study, we assessed the mutagenicity and metabolism-mediated cyt...
Assessment of estrogenic, mutagenic and antimutagenic activity of nemorosone
Camargo,Mariana S.; Varela,Soraya D.; Oliveira,Ana Paula S. de; Resende,Flávia Ap.; Cuesta-Rubio,Osmay; Vilegas,Wagner; Varanda,Eliana A.Currently, a wide range of research involving natural products is focused on the discovery of new drugs in many different therapeutic areas. A great number of the synthetic compounds on the market were derived from natural products, especially plants. Nemorosone is the major constituent of the floral resin of Clusia rosea Jacq., Clusiaceae, and in Cuban propolis. In vitro studies have shown cytotoxic activity i...
Antitumoral, mutagenic and (anti)estrogenic activities of tingenone and pristim...
Gomes,Juliana P. M.; Cardoso,Cássia R. P.; Varanda,Eliana A.; Molina,José-Manuel; Fernandez,Mariana F.; Olea,Nicolás; arlos,Iracilda Z.; Vilegas,WagnerCancer constitutes the second main mortality cause in the world, after cardiovascular diseases. In spite of the progresses in the chemotherapeutics treatments, many patients fail chemotherapy, mainly because of side effects or multi-drugs resistance, proving the need and importance of the research for new molecules with anticancer activity, more effective and with smaller adverse effects. Various compounds deri...
Mutagenicity of two species of the genus Alchornea measured by Salmonella micro...
Santos,Fabio V. dos; Calvo,Tamara R.; Cólus,Ilce Mara S.; Vilegas,Wagner; Varanda,Eliana A.Some species of the plant genus Alchornea (family Euphorbiaceae) are widely used in popular medicine, mainly in South America and in Africa. Several kinds of biological activity have been seen in the species: antioxidant, antifungal, anti-inflammatory, antibacterial, cytotoxic against tumor cell lines and inhibitory to the replication of HIV-1 and HIV-2. In Brazil, the species Alchornea castaneaefolia Willd. A....