2 documents found, page 1 of 1
Does dexamethasone act in neuropeptides SP and CGRP in neurogenic inflammation ...
Freitas,Jose Octavio Gonçalves de; Quieregatto,Paulo Rogério; Hochman,Bernardo; Lapin,Guilherme Abbud Franco; Mella,Stella Maria BotequioPURPOSE: To investigate the neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) after subcutaneous injection of dexamethasone prior to skin incision in rats.METHODS:Twenty seven Wistar-EPM-1 rats were randomly divided into three groups. The sham group (SG) of rats was injected with 0.9 % saline. The second group (Dexa) was injected with 1.0 mg/kg dexamethasone, and the third group (Dexa+) ...
The review of the methods to obtain non-neuronal cells to study glial influence...
Scorisa,Juliana Milani; Duobles,Tatiana; de Oliveira,Gabriela Pintar; Maximino,Jessica Ruivo; Chadi,GersonPURPOSE: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that displays a rapid evolution. Current treatments have failed to revert clinical symptoms because the mechanisms involved in the death of motoneuron are still unknown. Recent publications have put non-neuronal cells, particularly, astrocyte and microglia, in the scenario of pathophisiology of the disease. Animal models for ALS, ...