[No abstract available]
Eight new sulfide-based cyclic peptidomimetic analogues of solonamides A and B have been synthesized via solid-phase peptide synthesis and SN2’ reaction on a Morita–Baylis–Hillman (MBH) residue introduced at the N-terminal of a tetrapeptide. This last step takes advantage of the electrophilic feature of the MBH residue and represents a new cyclization strategy occurring. The analogues were prepared in moderate ...
São Tomé e Príncipe (STP), arquipélago de pequenas ilhas poderá ser um dos países mais pequenos do mundo, mas é igualmente um dos mais encantadores e desafiantes à prática clínica pediátrica. É um país de crianças e jovens, mais precisamente 86.060 (46%) para uma população total de 187.356 habitantes de acordo com o recenseamento de 2012.
Majority of children with pandemic influenza A (H1N1)pdm09 experience mild illness with full recovery without treatment. A previously healthy two and a half month-old girl was admitted to our paediatric intensive care unit because of severe respiratory failure with A (H1N1)pdm09 infection. Despite initial clinical improvement all attempts to extubate to non-invasive ventilation were unsuccessful and 2 to 3 week...
Sickle-cell anaemia (SCA) is a multi-system disease, associated with episodes of acute illness and progressive organ damage. Disease severity shows substantial variation and it is often a burden for adolescents. Complications such as leg ulcer and priapism have a significant impact on quality of life. There are still no definitive treatment guidelines available. Considering the embarrassing nature of priapism a...
Introdução e objectivos: A crescente afluência de crianças vítimas de maus tratos (MT) à urgência pediátrica (UP) do Hospital Prof. Doutor Fernando Fonseca (HFF) ou Amadora-Sintra, despoletou a necessidade de caracterizar esta realidade, compará-la com os dados nacionais, tendo como objectivo final a optimização da sua abordagem. Métodos:Análise das ficha deMTdas crianças observadas na UP entre 2000 e 2005. For...