13 documents found, page 1 of 2
SENTINEL : tackling dangerous nitazene opioids
Maria, Marisa H.; Pereira, Joana R. P.; Ferreira, Daniela R.; Barra, Bárbara F. C.; Antunes, Alexandra M. M.; Família, Carlos; Oliveira-Torres, EditePoster apresentado nas VI Jornadas Científicas Universitárias e Politécnicas Egas Moniz. Monte de Caparica, 24 a 28 de novembro 2025
UHPLC-MS/MS methodology for analysis of new synthetic opioids and hallucinogens...
Pereira, Joana; Antunes, Mónica; Neng, N.R.; Mustra, Carla; Franco, João; Fonseca, SuzanaBackground & Aims: New Psychoactive Substances (NPS) are a real contemporaneous threat, due to their potency, dangerousness, and lack of control/monitoring. The NPS group that has grown the most is the synthetic opioids group, where fentanyl and its analogues stand out. However, the emerging concerning synthetic opioids are nitazenes. Due to their high potency, even minimal consumption doses can lead to severe ...
Detection and quantification of selected cannabinoids in oral fluid samples by ...
Antunes, Mónica; Simões, Susana; Fonseca, Suzana; Franco, João; Gallardo, Eugenia; Barroso, MárioCannabis is the most widely consumed illicit drug worldwide. As consumption rates increase, partially due to the decriminalization of its use for medicinal and recreational purposes, analytical methods for monitoring different cannabinoids in several biological matrices have been developed. Herein, a simple and fast extraction procedure to extract natural cannabinoids from oral fluid (OF) samples was developed ...
Documenting human exposure to cannabinoids using oral fluid
Antunes, Mónica; Simões, Susana; Fonseca, Suzana; Franco, João Miguel; Gallardo, Eugenia; Barroso, MárioThe importance of studying non-conventional biological matrices such as oral fluid (OF) is increasingly being recognized. This sample presents several advantages, mainly related to its collection procedure: it is non-invasive, easy to perform by non-medical personnel, can be performed under supervision to prevent adulteration, and provides low biohazard risk. OF samples are more likely to contain parent drugs, ...
Estudo de estabilidade de controlo analítico em método multi-substâncias por LC...
Mustra, Carla; Fonseca, Suzana; Monsanto, Paula; Franco, João MiguelINTRODUÇÃO/OBJETIVOS O desenvolvimento e validação de métodos analíticos é uma tarefa fundamental e frequente do Serviço de Química e Toxicologia Forenses (SQTF) que envolve o estudo de vários parâmetros como modelo de calibração, seletividade, sensibilidade, exatidão, precisão, estabilidade, entre outros. O grau de complexidade de uma validação aumenta a par com o número de substâncias abrangidas pelo método, ...
Desenvolvimento e validação de um método analítico para a determinação de canab...
Antunes, Mónica; Simões, Susana; Fonseca, Suzana; Franco, João; Gallardo, Eugenia; Barroso, MárioA canábis é a droga de abuso mais consumida na Europa, pelo que várias metodologias analíticas têm sido desenvolvidas para a quantificação dos seus componentes em matrizes biológicas, especialmente sangue e urina. No entanto, cada vez mais se está a reconhecer a importância do estudo de matrizes biológicas não-convencionais, nomeadamente cabelo e fluido oral (ou saliva) – os seus procedimentos de recolha não sã...
Development and validation of a multi-substance method for routine analysis of ...
Matos, Francisco; Barroso, Mário; Antunes, Mónica; Franco, João; Fonseca, SuzanaPesticides play an important role in forensic toxicology and are usually classified as a single class of chemicals, but in fact there are several different types of compounds, including organophosphates, carbamates, pyrethroids or organochlorines, among others, with different toxicities. Pesticide analysis in post-mortem samples can be difficult due to the complexity of the samples and to the high toxicity of t...
Determination of biomarkers of cannabis consumption in hair samples: preliminar...
Antunes, Mónica; Fonseca, Suzana; Simões, Susana; Franco, João; Gallardo, Eugenia; Barroso, MárioOver 96 million European adults are estimated to have consumed illicit drugs at some point in their lives, and cannabis is still the most consumed drug. The Portuguese data is obtained using surveys, but this type of study has several disadvantages, such as under or overestimation of consumption rates, which may lead to biased conclusions.Consequently, it is desirable that these studies are accompanied by drug ...
Toxicological analysis of cocaine adulterants in blood samples
Gameiro, Rui; Costa, Suzel; Barroso, Mário; Franco, João; Fonseca, SuzanaBackground & Objectives According to the European Drug Report of 2017, cocaine was the second most widely used drug in 2016, with 3.5 million consumers between 15 and 64 years old. This pattern of consumption also occurs in Portugal (2012). Adulterants are pharmacologically active substances developed for medical purposes (analgesics, local anesthetics, antihistamines, anthelmintics and others). However, there ...
Interactions between tramadol and selective serotonin reuptake inhibitors anti ...
Fonseca, Suzana; Franco, JoãoBackground & Objectives Tramadol is very often prescribed for pain management in patients with depression in treatment with selective serotonin reuptake inhibitors (SSRI). Serotonergic antidepressants and its concomitant use with tramadol can lead to a drug–drug interaction, resulting in a decrease in the tramadol analgesic effect and a higher risk of serotonin syndrome caused by the accumulation of serotonin i...