5 documents found, page 1 of 1
Potential biological properties of lycopene in a self-emulsifying drug delivery...
Báo, Sônia Nair; Machado, Manuela; Silva, Ana Luisa da; Melo, Adma; Cunha, Sara; Sousa, Sérgio S.; Malheiro, Ana Rita; Fernandes, RuiIn recent years, lycopene has been highlighted due to its antioxidant and anti-inflammatory properties, associated with a beneficial effect on human health. The aim of this study was to advance the studies of antioxidant and anti-inflammatory mechanisms on human keratinocytes cells (HaCaT) of a self-emulsifying drug delivery system (SEDDS) loaded with lycopene purified from red guava (nanoLPG). The characterist...
Lycopene-rich extract from red guava ( Psidium guajava L.) displays cytotoxic e...
Santos, Raimunda C. dos; Ombredane, Alicia S.; Souza, Jéssica Maria T.; Vasconcelos, Andreanne G.; Plácido, Alexandra; Amorim, Adriany das G.N.This study investigated a lycopene-rich extract from red guava (LEG) for its chemical composition using spectrophotometry, mass spectrometry, attenuated total reflectance-fourier transform infrared spectroscopy (ATR-FTIR), and computational studies. The cytotoxic activity of LEG and the underlying mechanism was studied in human breast adenocarcinoma cells (MCF-7), murine fibroblast cells (NIH-3T3), BALB/c murin...
Structure-function studies of BPP-BrachyNH 2 and synthetic analogues thereof wi...
Arcanjo, Daniel D.R.; Vasconcelos, Andreanne G.; Nascimento, Lucas A.; Mafud, Ana Carolina; Plácido, Alexandra; Alves, Michel M.M.The vasoactive proline-rich oligopeptide termed BPP-BrachyNH2 (H-WPPPKVSP-NH2) induces in vitro inhibitory activity of angiotensin I-converting enzyme (ACE) in rat blood serum. In the present study, the removal of N-terminal tryptophan or C-terminal proline from BPP-BrachyNH2 was investigated in order to predict which structural components are important or required for interaction with ACE. Furthermore, the tox...
Layer-by-layer films containing peptides of the Cry1Ab16 toxin from Bacillus th...
Plácido, Alexandra; Farias, Emanuel Airton de Oliveira; Marani, Mariela M.; Vasconcelos, Andreanne G.; Mafud, Ana C.; Mascarenhas, Yvonne P.Cry1Ab16 is a toxin of crystalline insecticidal proteins that has been widely used in genetically modified organisms (GMOs) to gain resistance to pests. For the first time, in this study, peptides derived fromthe immunogenic Cry1Ab16 toxin (from Bacillus thuringiensis) were immobilized as layer-by-layer (LbL) films. Given the concern about food and environmental safety, a peptide with immunogenic potential, PcL...
In Silico, In Vitro and In Vivo Toxicological Assessment of BPP-BrachyNH2, A Va...
Arcanjo, Daniel D. R.; Mafud, Ana Carolina; Vasconcelos, Andreanne G.; Silva-Filho, José Couras da; Amaral, Maurício P. M.; Brito, Lucas M.BPP-BrachyNH2 is a proline-rich oligopeptide (PRO) firstly identified in skin secretion of the frog Brachycephalus ephippium, which possess in vitro inhibitory activity of angiotensin-I converting enzyme (ACE) and endothelium-dependent vasorelaxant activity. Considering its potential application in the treatment of cardiovascular diseases, the present work assessed the toxicological profile of the BPP-BrachyNH2...