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Multiple autoimmune syndrome: Clinical, immunological and genotypic characteriz...
Fidalgo, M; Faria, R; Carvalho, C; Carvalheiras, G; Mendonça, D; Farinha, F; da Silva, BM; Vasconcelos, CIntroduction: The existence of subphenotypes common to several autoimmune diseases (AIDs) suggests a shared physiopathology - autoimmune tautology. Multiple Autoimmune Syndrome (MAS) - the coexistence of three or more AIDs in one person-, best illustrates that polyautoimmunity is more than a coincidence. Objectives: Characterize and compare the monoautoimmune and MAS patients. Understand if clustering of AIDs l...
The impact of a community-based food education programme on dietary pattern in ...
Vasconcelos, C; Cabral, M; Ramos, E; Mendes, RThe purpose of this study was to analyse the effects of a food education programme, with easy-to-implement strategies integrated in a community-based exercise programme, on dietary pattern of patients with type 2 diabetes (T2D). Thirty-three patients (65.4 ± 5.9 years old) were engaged in a 9-month randomised controlled trial: a supervised exercise programme (control group [CON]; n = 15; combined exercise; thre...
Nutrition-related knowledge and its determinants in middle-aged and older patie...
Vasconcelos, C; Almeida, A; Sá, C; Viana, J; Cabral, M; Ramos, E; Mendes, RAims: To analyse nutrition-related knowledge and its determinants in middle-aged and older patients with T2D. Methods: In a cross sectional study, a total of 116 participants with T2D, aged 50–80 years, were recruited in primary health care. Data was collected by a self-reported questionnaire — the modified version of General Nutrition Knowledge Questionnaire (0–56 points). Sociodemographic data was also collec...
Weaning Practices in Phenylketonuria Vary Between Health Professionals in Europe
Pinto, A; Adams, S; Ahring, K; Allen, H; Almeida, M F; Garcia-Arenas, D; Arslan, N; Assoun, M; Atik Altınok, Y; Barrio-Carreras, D; Belanger Quintana, AIn phenylketonuria (PKU), weaning is considered more challenging when compared to feeding healthy infants. The primary aim of weaning is to gradually replace natural protein from breast milk or standard infant formula with solids containing equivalent phenylalanine (Phe). In addition, a Phe-free second stage L-amino acid supplement is usually recommended from around 6 months to replace Phe-free infant formula. ...
Weaning Practices in Phenylketonuria Vary Between Health Professionals in Europe
Pinto, A; Adams, S; Ahring, K; Allen, H; Almeida, MF; Garcia-Arenas, D; Arslan, N; Assoun, M; Atik Altınok, Y; Barrio-Carreras, D; Belanger Quintana, AIn phenylketonuria (PKU), weaning is considered more challenging when compared to feeding healthy infants. The primary aim of weaning is to gradually replace natural protein from breast milk or standard infant formula with solids containing equivalent phenylalanine (Phe). In addition, a Phe-free second stage L-amino acid supplement is usually recommended from around 6 months to replace Phe-free infant formula. ...
The Impact of a Community-Based Food Education Program on Nutrition-Related Kno...
Vasconcelos, C; Almeida, A; Cabral, M; Ramos, E; Mendes, RThe purpose of this study was to evaluate the impact of a community-based food education program on nutrition-related knowledge in middle-aged and older patients with type 2 diabetes (T2D). Participants (n = 36; 65.9 ± 6.0 years old) were recruited in primary health care to a 9-month community-based lifestyle intervention program for patients with T2D and randomly assigned to an exercise program (control group;...
Parasitic Myoma: A Rare Presentation of a Common Disease
Aguilar, S; Vasconcelos, C; Redondo, L; Fatela, AParasitic myomas are a rare form of uterine leiomyomas. Distinction from other abdominal masses may be difficult, due to parasitic leiomyomas' variable anatomic locations and clinical manifestations. We describe the case of a 45 years-old woman, presenting with abdominal pain and a large pelvic mass that turned out to be a parasitic myoma at surgical assessment. Histological analysis confirmed the intraoperativ...
Early Feeding Practices in Infants with Phenylketonuria Across Europe
Pinto, A; Adams, S; Ahring, K; Allen, H; Almeida, MF; Garcia-Arenas, D; Arslan, N; Assoun, M; Atik Altınok, Y; Barrio-Carreras, D; Belanger Quintana, AIn infants with phenylketonuria (PKU), dietary management is based on lowering and titrating phenylalanine (Phe) intake from breast milk or standard infant formula in combination with a Phe-free infant formula in order to maintain blood Phe levels within target range. Professionals use different methods to feed infants with PKU and our survey aimed to document practices across Europe.
Two Separate Effects Contribute to Regulatory T Cell Defect in Systemic Lupus E...
Costa, N; Marques, O; Godinho, SI; Carvalho, C; Leal, B; Figueiredo, AM; Vasconcelos, C; Marinho, A; Moraes-Fontes, MF; Gomes da Costa, A; Ponte, CForkhead box P3 (FoxP3)+ regulatory T cells (Tregs ) are functionally deficient in systemic lupus erythematosus (SLE), characterized by reduced surface CD25 [the interleukin (IL)-2 receptor alpha chain]. Low-dose IL-2 therapy is a promising current approach to correct this defect. To elucidate the origins of the SLE Treg phenotype, we studied its role through developmentally defined regulatory T cell (Treg ) su...
A3.6 Two components contributing to reduced treg surface CD25 in sle patients a...
Costa, N; Marques, O; Godinho, S; Carvalho, C; Leal, B; Vasconcelos, C; Marinho, A; Moraes-Fontes, M F; Gomes da Costa, A; Ponte, C; Marques, RBackground FOXP3+ regulatory T-cells (Tregs) in Systemic Lupus Erythematosus (SLE) are in a functionally deficient state with a characteristic reduction or absence of surface CD25 (the IL-2 receptor alpha chain). Genetic variation in the CD25-encoding IL2RA locus is associated with other autoimmune disorders.