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Aerocyte specification and lung adaptation to breathing is dependent on alterna...
Fidalgo, Marta F; Fonseca, Catarina; Caldas, Paulo; Raposo, Alexandre; Balboni, Tania; Henao Mišíková, Lenka; Grosso, Ana R.; Vasconcelos, FranciscaAdaptation to breathing is a critical step in lung function and it is crucial for organismal survival. Alveoli are the lung gas exchange units and their development, from late embryonic to early postnatal stages, requires feedbacks between multiple cell types. However, how the crosstalk between the alveolar cell types is modulated to anticipate lung adaptation to breathing is still unclear. Here, we uncovered a...
Endothelial cell invasion is controlled by dactylopodia
Figueiredo, Ana; Barbacena, Pedro; Russo, Ana; Vaccaro, Silvia; Ramalho, Daniela; Pena, Andreia; Lima, Aida Pires; Rua Ferreira, Rita; Fidalgo, MartaSprouting angiogenesis is fundamental for development and contributes to cancer, diabetic retinopathy, and cardiovascular diseases. Sprouting angiogenesis depends on the invasive properties of endothelial tip cells. However, there is very limited knowledge on how tip cells invade into tissues. Here, we show that endothelial tip cells use dactylopodia as the main cellular protrusion for invasion into nonvascular...
Non-canonical Wnt signaling regulates junctional mechanocoupling during angioge...
Carvalho, Joana R.; Fortunato, Isabela C.; Fonseca, Catarina; Pezzarossa, Anna; Barbacena, Pedro; Dominguez-Cejudo, Maria AngelesMorphogenesis of hierarchical vascular networks depends on the integration of multiple biomechanical signals by endothelial cells, the cells lining the interior of blood vessels. Expansion of vascular networks arises through sprouting angiogenesis, a process involving extensive cell rearrangements and collective cell migration. Yet, the mechanisms controlling angiogenic collective behavior remain poorly underst...