3 documents found, page 1 of 1
Envolvimento de receptores tipo 1 da angiotensina II (AT1R) em modelo animal de...
Vasconcelos, Germana SilvaSchizophrenia is a serious and chronic mental disorder that affects more than 21 million people in the world. The main symptoms are: positive (hallucinations, delusions and paranoia), negative (social isolation, anedonia and alogia) and cognitive (deficits in working memory and attention). There is a significant influence of sex on the prognosis of this disease, severity of symptoms and response to antipsychoti...
Reversão de sintomas comportamentais tipo-esquizofrenia e alterações neuroquími...
Vasconcelos, Germana SilvaSchizophrenia is partially mimicked by the repeated administration of ketamine (KET) being this model sensitive to atypical antipsychotics. Oxidative imbalance is an important alteration seen in schizophrenia. Alpha-lipoic acid (ALA) is a natural acid synthesized in human tissues presenting antioxidant properties. Herein we aimed to determine the effect of ALA alone or combined with clozapine (CZP) in the rever...
Monocrotaline : histological damage and oxidant activity in brain areas of mice
Honório Junior, José Eduardo Ribeiro; Vasconcelos, Germana Silva; Rodrigues, Francisca Taciana Sousa; Sena Filho, José Guedes; Barbosa-Filho, José MariaThis work was designed to study MCT effect in histopathological analysis of hippocampus (HC) and parahippocampal cortex (PHC) and in oxidative stress (OS) parameters in brain areas such as hippocampus (HC), prefrontal cortex (PFC), and striatum (ST). Swiss mice (25–30 g) were administered a single i.p. dose of MCT (5, 50, or 100 mg/kg) or 4% Tween 80 in saline (control group). After 30 minutes, the animals were...