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Evaluation of the anti-inflammatory activity of riparin II (O-methil- N-2-hidro...
Carvalho, Alyne Mara Rodrigues de; Rocha, Nayrton Flávio Moura; Vasconcelos, Leonardo Freire; Rios, Emiliano Ricardo Vasconcelos; Dias, Marília LeiteRiparin II (RipII), an alkamide isolated from the green fruit of Aniba riparia, was tested in the various animal models of inflammation to investigate its anti-inflammatory activity. Male Wistar rats (180–240 g) were treated with RipII by gavage at doses 25 or 50 mg/kg, before initiating the inflammatory responses. The tests used were paw edema induced by carrageenan, dextran, histamine or serotonin; peritoniti...
TRP and ASIC channels mediate the antinociceptive effect of citronellyl acetate
Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Carvalho, Alyne Mara Rodrigues; Vasconcelos, Leonardo Freire; Dias, Marília LeiteBackground: Citronellyl acetate (CAT), a monoterpene product of the secondary metabolism of plants, has been shown in the literature to possess several different biological activities. However, no antinociceptive abilities have yet been discussed. Here, we used acute pain animal models to describe the antinociceptive action of CAT. Methods: The acetic acid-induced writhing test and the paw-licking test, in whic...