4 documents found, page 1 of 1
Associação entre polimorfismos nos genes IL 10, IL 4, CTLA4 E Diamino oxidase e...
Vasconcelos, Luciana Mabel FerreiraNonsteroidal anti-inflammatory drugs (NSAIDs) are responsible for 20to 25% of the adverse drug reactions. In susceptible individuals, itcan occurNSAIDs-exacerbated respiratory disease, NSAIDs-exacerbated cutaneous disease, NSAIDs-induced angioedema/urticaria and angioedema/ hives or anaphylaxisinduced to a single NSAID. The mechanisms of these reactions are not totally known, but there is high evidence that one...
Association of IL10 , IL4 , IFNG , and CTLA4 gene polymorphisms with efavirenz ...
Rodrigues, Raphael de Oliveira; Rabenhorst, Silvia Helena Barem; Carvalho, Paulo Germano de; Sasahara, Greyce Luri; Vasconcelos, Luciana Mabel FerreiraSUMMARY: We evaluated interleukin-10 ( IL10 ) － 592 C / A, IL4 － 589 C / T, interferon gamma ( IFNG ) ＋ 874 A / T, cytotoxic T-lymphocyte-associated antigen 4 ( CTLA4 ) ＋ 49 A / G gene polymorphisms associated with efavirenz hypersensitivity reaction. A total of 63 human immunodeficiency virus-positive patients under treatment at a public hospital were included in the study, of whom 21 presented with efavirenz ...
Polymorphism of IL10, IL4, CTLA4, and DAO genes in cross-reactive nonsteroidal ...
Vasconcelos, Luciana Mabel Ferreira; Rodrigues, Raphael de Oliveira; Albuquerque, Andressa Almeida; Barroso, Gabrielle Dantheias; Sasahara, Greyce LuriOur aim was to evaluate genetic polymorphism of molecules involved in immunoregulatory/allergic processes in patients who presented with cutaneous hypersensitivity caused by chemically unrelated nonsteroidal anti-inflammatory drugs. Polymorphisms at IL10 (–1082 G>A), IL4 (–589 C>T), CTLA4 (+49A>G), and DAO (+8956 C>G) genes were studied in 55 cases and 97 controls by the polymerase chain reaction-restriction fr...
Investigação clínico laboratorial de pacientes com suspeita de reações de hiper...
Vasconcelos, Luciana Mabel FerreiraAllergic drug reactions account for 6.5% of hospital admissions, prolonged hospitalization 15.1% of patients and are severe in 6.7% of patients. There are difficulties in understanding the immune mechanisms, diagnosis and treatment of patients. Therefore, such reactions are considered a Public Health problem. The objective of this study was to describe the cases of patients with suspected allergic hypersensitiv...