95 documents found, page 1 of 10

Isoquinolinequinone N-oxides as potent antitumor compounds against pancreatic c...

Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive malignancies, being the 7th leading cause of cancer-related mortality worldwide. PDAC remains associated with an extremely poor prognosis, owing to drug resistance and to the lack of alternative therapeutic options. Standard chemotherapy typically involves gemcitabine, either alone or combined with paclitaxel. Moreover, Chitinase-...

From resistance to sensitivity in non-small cell lung cancer: newly established...

Background: Non-small cell lung cancer (NSCLC) is the most common form of lung cancer and presents a low 5-year survival rate [1]. Standard treatment of NSCLC includes chemotherapeutic drugs, such as taxanes and platinum-based agents. However, cancer cells may acquire resistance to multiple unrelated chemotherapeutic agents, known as multidrug resistance (MDR), which significantly limits treatment options [2]. ...

Synthesis of Novel Methyl 3-(hetero)arylthieno[3,2-b]pyridine-2-carboxylates an...

A series of novel functionalized methyl 3-(hetero)arylthieno[3,2-<i>b</i>]pyridine-2-carboxylates <b>2a</b>–<b>2h</b> were synthesized by C-C Pd-catalyzed Suzuki-Miyaura cross-coupling of methyl 3-bromothieno[3,2-<i>b</i>]pyridine-2-carboxylate with (hetero)aryl pinacol boranes, trifluoro potassium boronate salts or boronic acids. Their antitumoral potential was evaluated in two triple negative breast cancer (T...

Urinary Biomarkers in Bladder Cancer: Where Do We Stand and Potential Role of E...

Extracellular vesicles (EVs) are small membrane vesicles released by all cells and involved in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipids, and proteins constantly transferred between different cell types, contributing to autocrine and paracrine signaling. In recent years, they have been shown to play vital roles, not only in normal biological functions, but also in pathol...

Urinary biomarkers in bladder cancer : where do we stand and potential role of ...

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open accessarticle distributed under the terms and conditions of the Creative Commons Attribution(CC BY) license (http://creativecommons.org/licenses/by/4.0/).; Extracellular vesicles (EVs) are small membrane vesicles released by all cells and involved in intercellular communication. Importantly, EVs cargo includes nucleic acids, lipid...

Eucalyptus globulus Labill. decoction extract inhibits the growth of NCI-H460 c...

Eucalyptus globulus Labill. is a widespread evergreen plant belonging to the Myrtaceae family. Several species of Eucalyptus are known to have a plethora of medicinal properties, particularly anti-tumor activity, which prompts the study of the chemical composition and bioactivity of extracts from this plant. Hereby, the main aims of this work were to (i) profile the phenolic compounds in E. globulus extracts pr...

Melissa officinalis L. ethanolic extract inhibits the growth of a lung cancer c...

Melissa officinalis is a plant from the family Lamiaceae, native in Europe particularly in the Mediterranean region. Given our interest in identifying extracts and compounds capable of inhibiting tumor cell growth, and given the antioxidant content and the high consumption of Melissa officinalis in Portugal, this study aimed to test the tumor cell growth inhibitory activity of five different extracts of this pl...

Achillea millefolium L. hydroethanolic extract inhibits growth of human tumor c...

Suppression of spindly delays mitotic exit and exacerbates cell death response ...

Microtubule-targeting agents (MTAs) are used extensively for the treatment of diverse types of cancer. They block cancer cells in mitosis through the activation of the spindle assembly checkpoint (SAC), the surveillance mechanism that ensures accurate chromosome segregation at the onset of anaphase. However, the cytotoxic activity of MTAs is limited by premature mitotic exit (mitotic slippage) due to SAC silenc...

The cell growth inhibitory effect of an aqueous extract of Tuberaria lignosa in...

Tuberaria lignosa (Sweet) Samp. is found in European regions. This plant has antioxidant properties due to its composition in ascorbic acid and phenolic compounds [1]. Given its antioxidant properties and its large traditional use, the aim of this work was to study the tumor cell growth inhibitory potential of aqueous extracts from T. lignosa (prepared by infusion and decoction). Cell growth was accessed by the...