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2020 taxonomic update for phylum Negarnaviricota (Riboviria: Orthornavirae), in...

Kuhn, Jens H; Adkins, Scott; Alioto, Daniela; Alkhovsky, Sergey V; Amarasinghe, Gaya K; Anthony, Simon J; Avsic-Zupanc, Tatjana; Ayll?n, Mar?a A

This work was supported in part through Laulima Government Solutions, LLC prime contract with the US National Institute of Allergy and Infectious Diseases (NIAID) under Contract No. HHSN272201800013C. J.H.K. performed this work as an employee of Tunnell Government Services (TGS), a subcontractor of Laulima Government Solutions, LLC under Contract No. HHSN272201800013C. This project has been funded in whole or i...

Date: 2020   |   Origin: Oasisbr

Molecular mechanism for the control of virulent Toxoplasma gondii infections in...

Murillo-León, Mateo; Müller, Urs B; Zimmermann, Ines; Singh, Shishir; Widdershooven, Pia; Campos, Cláudia; Alvarez, Catalina; Könen-Waisman, Stephanie

Some strains of the protozoan parasite Toxoplasma gondii (such as RH) are virulent in laboratory mice because they are not restricted by the Immunity-Related GTPase (IRG) resistance system in these mouse strains. In some wild-derived Eurasian mice (such as CIM) on the other hand, polymorphic IRG proteins inhibit the replication of such virulent T. gondii strains. Here we show that this resistance is due to dire...


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