11 documents found, page 1 of 2
Preconditioning with L-Ala-Gln reduces the expression of inflammatory markers (...
Oliveira, Leidelamar Rosário Alves de; Albuquerque, Andréa de Oliveira; Silva, Cícero Igor Simões Moura; Silva, Jussara MathielePurpose: To evaluate the neuroprotective effect of L-alanyl-glutamine in a gerbil model of brain ischemia-reperfusion injury based on immunohistochemical quantification of pro-inflammatory and cell activation biomarkers (TNF-α, NF-κB, IL-6 and HO-1). Methods: Male gerbils weighing 100-180 g were pretreated with either 0.75 g/kg L-Ala-Gln (n=18) or 2.0 mL saline (n=18) administered i.v. 30 minutes before the bil...
Presence of new mutations in the TP53 gene in patients with low-risk myelodyspl...
Duarte, Fernando Barroso; Lemes, Romélia Pinheiro Gonçalves; Santos, Talyta Ellen de Jesus dos; Barbosa, Maritza CavalcanteBackground Myelodysplastic syndromes are heterogeneous disorders. Patients with myelodysplastic syndrome disease often have ineffective hematopoiesis, cytopenias, blood cell dysplasia in one or more cell types, and are at high risk for developing acute myeloid leukemia. In myelodysplastic syndrome, mutations of TP53 gene are usually associated with complex karyotype and confer a worse prognosis. In the present ...
Development of a subcutaneous endometriosis rat model
Pereira, Francisco Edson Ximenes Gomes; Almeida, Paulo Roberto Carvalho de; Dias, Bruno Hállan Meneses; Vasconcelos, Paulo Roberto Leitão dePURPOSE: To present a rat model of subcutaneous endometriosis for the study of pathophysiology and the effects of drugs. METHODS: Fifty three-month-old female Wistar rats (Rattus norvergicus) were distributed into one control group and four treatment groups: estradiol (2.5; 5; 10mg/kg sc), medroxyprogesterone acetate (0.5; 2; 5mg/kg sc), triptorelin pamoate (0.18; 0.56mg/kg sc) and acetylsalicylic acid (3mg/kg ...
Preconditioning with L-alanyl-glutamine upon cerebral edema and hypocampus red ...
Vasconcelos, Paulo Roberto Cavalcante de; Guimarães, André Brito Bastos; Campelo, Marcio Wilker Soares; Vasconcelos, Paulo Roberto Leitão dePURPOSE: To evaluate the effects of the dipeptide L-alanyl-glutamine (L-Ala-Gln) as a preconditioning agent to potentially promote reduction in the intensity of lesion or induction of resilience in rats subjected to global cerebral ischemia/reperfusion (I/R) injury. METHODS: Thirty-six male Wistar rats weighing 280-300g were randomly assigned to six groups (n=6). Groups Sham 1h and 24h were treated with saline ...
Fructo-oligosaccharide effects on serum cholesterol levels. An overview
Costa, Graciana Teixeira; Abreu, Giselle Castro de; Guimarães, André Brito Bastos; Vasconcelos, Paulo Roberto Leitão de; Guimarães, Sergio BotelhoPURPOSE: To address the effects of fructooligosaccharides (FOS) intake on serum cholesterol levels. METHODS: We performed a search for scientific articles in MEDLINE database from 1987 to 2014, using the following English keywords: fructooligosaccharides; fructooligosaccharides and cholesterol. A total of 493 articles were found. After careful selection and exclusion of duplicate articles 34 references were sel...
Preconditioning with mono and polyunsaturated fatty acids and low-intensity ele...
Cardoso, Maria dos Prazeres Carneiro; Albuquerque, Andréa de Oliveira; Girão, Virgínia Cláudia Carneiro; Pompeu, Margarida Maria de LimaPURPOSE: To evaluate the effects of preconditioning with oils mixes containing ω3/ω6/ω9 associated with micro-currents on skin repair in rats. METHODS: One-hundred and eight Wistar rats randomized into G-1, G-2 and G-3 groups were treated with saline (0.9%), mix 1 (corn+soybean oils) and mix 2 (olive+canola+flaxseed oils), respectively, in a single dose (0.01ml/g) by gavage. Next, each group was subdivided into...
Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of therma...
Campelo, Ana Paula Bomfim Soares; Campelo, Márcio Wilker Soares; Brito, Gerly Anne de Castro; Jamacaru, Francisco Vagnaldo FechinePURPOSE: To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury. METHODS: Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 ...
Nutraceutical preconditioning with arginine and oil mixes. Effects on inflammat...
Tavares, Lílian de Lima; Cavalcante, Karla Pinheiro; Campelo, Márcio Wilker Soares; Coutinho, Leonam Gomes; Medeiros, Silvia Regina Batistuzzo deABSTRACTPURPOSE: To investigate whether there is any effect resulting from preconditioning with nutraceutical supplementation containing arginine and oil mixes with high ω9:ω6 ratio and low ω6:ω3 ratio containing EPA and DHA, ALA fatty acids on inflammatory mediators, antioxidant and lipid profile modulation in surgical trauma.METHODS: Twenty-six men scheduled for radical prostatectomy were randomized into thre...
Tumor suppressor p53 protein expression : prognostic significance in patients w...
Duarte, Fernando Barroso; Gonçalves, Romelia Pinheiro; Barbosa, Maritza Cavalcante; Rocha Filho, Francisco Dário; Santos, Talyta Ellen de Jesus dosBackground: At the time of diagnosis, more than 50% of patients with myelodysplastic syn- drome have a normal karyotype and are classified as having a favorable prognosis. However, these patients often show very variable clinical outcomes. Furthermore, current diagnostic tools lack the ability to look at genetic factors beyond karyotyping in order to determine the cause of this variability. Objective: To evalua...
Glutamine and ornithine alpha-ketoglutarate supplementation on malate dehydroge...
Guimarães Filho, Artur; Cunha, Rodrigo Maranguape Silva da; Vasconcelos, Paulo Roberto Leitão de; Guimarães, Sergio BotelhoPURPOSE: To evaluate the relative gene expression (RGE) of cytosolic (MDH1) and mitochondrial (MDH2) malate dehydrogenases enzymes in partially hepatectomized rats after glutamine (GLN) or ornithine alpha-ketoglutarate (OKG) suplementation. METHODS: One-hundred and eight male Wistar rats were randomly distributed into six groups (n=18): CCaL, GLNL and OKGL and fed calcium caseinate (CCa), GLN and OKG, 0.5g/Kg b...