17 documents found, page 1 of 2
Efeitos comportamentais, neuroquímicos e bioquímicos do etanol em roedores, na ...
Vasconcelos, Silvânia Maria MendesIn the present work, behavioral, neurochemical (determination of monoamines and metabolites, as well as, aminoacids leveis in striatum) and biochemical (glucose, transaminases, lipoproteins and apoproteins) alterations produced by ethanol alone and in association with glutamatergic, dopaminergic and opioid antagonists were studied. Male Wistar rats (150-230 g) and Swiss mice (28-34 g) in two experimental protoc...
Neurociência e biologia celular na escola
Pereira, Yuri Freitas e Silva; Campos, Fernanda Maria Teófilo; Rocha, Talita Magalhães; Neves, Julliana Catharina de SousaINTRODUÇÃO. A Universidade é um espaço muito vislumbrado pelos jovens que concluem o ensino médio e que veem no ensino superior um horizonte a ser explorado com varias possibilidades. Para que eles conheçam suas opções e tenham uma familiaridade com a futura instituição, as ações de extensão são uma experiência concreta trazendo uma melhor percepção de quem e como se produz os conhecimentos. OBJETIVO. Com isso,...
α-Lipoic acid as adjunctive treatment for schizophrenia : an open-label trial
Sanders, Lia Lira Olivier; Menezes, Carlos Eduardo de Souza; Chaves Filho, Adriano José Maia; Viana, Glautemberg de Almeida; Fechine, Francisco VagnaldoPurpose/Background: Accumulating evidence suggests an involvement of oxidative stress in the pathophysiology of schizophrenia. This offers a hypothesis-derived therapeutic approach to hinder oxidative damage and its clinical sequelae. α-Lipoic acid (ALA) is a powerful natural antioxidant indicated to treat diabetic neuropathy. Methods/Procedures: In this pilot investigation, we administered ALA (100 mg/d) for 4...
IDO chronic immune activation and tryptophan metabolic pathway : a potential pa...
Chaves Filho, Adriano José Maia; Lima, Camila Nayane Carvalho; Vasconcelos, Silvânia Maria Mendes; Lucena, David Freitas de; Maes, MichaelObesity and depression are among the most pressing health problems in the contemporary world. Obesity and depression share a bidirectional relationship, whereby each condition increases the risk of the other. By in- ference, shared pathways may underpin the comorbidity between obesity and depression. Activation of cell- mediated immunity (CMI) is a key factor in the pathophysiology of depression. CMI cytokines,...
Neonatal Immune Challenge with Lipopolysaccharide Triggers Long-lasting sex- an...
Custódio, Charllyany Sabino; Mello, Bruna Stefânia Ferreira; Chaves Filho, Adriano José Maia; Lima, Camila Nayane de CarvalhoEarly-life challenges, particularly infections and stress, are related to neuropsychiatric disorders such as autism and schizophrenia. Here, we conducted a wide range of behavioral tests in periadolescent (postnatal day (PN) 35) and adult (PN70) Swiss mice neonatally challenged with LPS on PN5 and -7, to unveil behavioral alterations triggered by LPS exposure. Immune and neurotrophic (brain-derived neurotrophic...
N-acetylcysteine attenuates nicotine-induced kindling in female periadolescent ...
Okamura, Adriana Mary Nunes Costa; Gomes, Patrícia Xavier L.; Oliveira, Gersilene V. de; Araújo, Fernanda Yvelize R. de; Tomaz, Viviane S.Kindling We recently demonstrated that female periadolescent rats are more vulnerable to nicotine (NIC)-induced kindling than their male counterparts. Furthermore, we evidenced that decreases in brain antioxidative defenses may contribute to this gender difference. Here we aimed to determine the preventive effects of the antioxidant N-acetyl cysteine (NAC) against NIC-kindling in female periadolescent rats. To ...
A utilização de escalas de avaliação como recurso terapêutico em pacientes aten...
Matos, Maria Teresa Soares; Bastos, Evelyne Nunes Ervedosa; Matos, Edna Colangelo; Vasconcelos, Silvânia Maria MendesThe aim of the present study was to assess the use of the “Inventory of Drinking Situations” and the “Inventory of Drug Taking Situations” in patients seen at the drug rehabilitation center in a psychiatric public hospital in Fortaleza-CE. Patients attending the service were included in the study (n=21). A total of 9 alcohol dependents and 12 drug dependents completed the survey. The results showed an elevated ...
Problemática da administração de antimicrobiano em recém-nascidos
Chaves, Edna Maria Camelo; Queiroz, Maria Veraci Oliveira; Almeida, Paulo César; Moreira, Thereza Maria Magalhães; Vasconcelos, Silvânia Maria MendesThe use of antimicrobials is frequent in the newborn, what requires care in its administration. The aim of this research was to verify the association among the following variables: gender, weight, gestational age, indication of antimicrobials and alterations occurred during newborns’ therapy in a neonatal unit. It is a transversal, descriptive study, conducted in a neonatal unit. The sample was composed of 94 ...
Prevention and reversal of ketamine-induced schizophrenia related behavior by m...
Monte, Aline Santos; Souza, Greicy Coelho de; McIntyre, Roger S.; Soczynska, Joanna K.; Santos, Júnia Vieira dos; Cordeiro, Rafaela CarneiroIt has been hypothesized that oxidative imbalance and alterations in nitrergic signaling play a role in the neurobiology of schizophrenia. Preliminary evidence suggests that adjunctive minocycline treatment is efficacious for cognitive and negative symptoms of schizophrenia. This study investigated the effects of minocycline in the prevention and reversal of ketamine-induced schizophrenia-like behaviors in mice...
Complicações da sífilis congênita : uma revisão de literatura
Albuquerque, Greicy Machado Aguiar de; Chaves, Edna Maria Camelo; Sampaio, Luis Rafael Leite; Dias, Katia Cilene FerreiraCongenital syphilis occurs after transplacentary infection by the agent Treponema pallidum. The consequences of lack of treatment of the newborn can lead to irreversible consequences, such as deafness, blindness and mental retardation. The study aims to update the literature about the complications of congenital syphilis. This is a descriptive study and literature review. Data collection was conducted reviewing...