7 documents found, page 1 of 1
Rapid and long-lasting antidepressant-like effects of ketamine and their relati...
Viana, Glauce S. B.; Vale, Eduardo Mulato do; Araujo, A. R. A. de; Coelho, N. C.; Andrade, S. M.; Costa, R. O. da; Aquino, Pedro Everson Alexandre deKetamine (KET) is an N-methyl-D-aspartate (NMDA) antagonist with rapid and long-lasting antidepressant effects, but how the drug shows its sustained effects is still a matter of controversy. The objectives were to evaluate the mechanisms for KET rapid (30 min) and long-lasting (15 and 30 days after) antidepressant effects in mice. A single dose of KET (2, 5, or 10 mg/kg, po) was administered to male Swiss mice ...
Involvement of the dopaminergic system in the antidepressant-like effect of the...
Abreu, Ticiana Monteiro; Monteiro, Valdécio Silvano; Martins, Ana Beatriz Souza; Teles, Felipe Barros; Rivanor, Renata Line da ConceiçãoThis study aimed at evaluating the antidepressant-like action of the marine alga Solieria filiformis lectin (SfL) and to investigate the participation of the monoaminergic system in this action. For this, male Swiss mice (n=10) were pretreated with intravenous injections (i.v.) of SfL (1, 3 or 9mg/kg) and submitted to open field (OFT), tail suspension (TST), forced swimming (FST), elevated plus-maze (EPMT) and ...
Anxiolytic-Like effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin ...
Melo, Carla Thiciane Vasconcelos de; Monteiro, Andreisa Paiva; Leite, Caroline Porto; Araújo, Fernando Luiz Oliveira de; Lima, Vera Targino MoreiraMELO, C. T. V. de. et al. Anxiolytic-Like effects of (O-Methyl)-N-2,6-dihydroxybenzoyl-tyramine (Riparin III) from Aniba riparia (NEES) MEZ (Lauraceae) in mice. Biological & Pharmaceutical Bulletin, Tokyo, v. 29, n.3, p. 451-454, mar. 2006.; This work presents behavioral effects of (O-methyl)-N-2,6-dihydroxybenzoyl-tyramine (riparin III) isolated from the unripe fruit of Aniba riparia (NEES) MEZ (Lauraceae) in ...
Antidepressant-like effect of Hoodia gordonii in a forced swimming test in mice...
Citó, M. C. O.; Silva, Maria Izabel Gomes; Santos, Luciana Kelly Ximenes; Fernandes, M. L.; Melo, Francisca Helvira CavalcanteHoodia gordonii is a plant species used traditionally in southern Africa to suppress appetite. Recently, it has been associated with a significant increase in blood pressure and pulse rate in women, suggesting sympathomimetic activity. The present study investigated the possible antidepressant-like effects of acute and repeated (15 days) administration of H. gordonii extract (25 and 50 mg/kg, po) to mice expose...
Antinociceptive activity of carvacrol (5-isopropyl-2- methylphenol) in mice
Melo, Francisca Helvira Cavalcante; Rios, Emiliano Ricardo Vasconcelos; Rocha, Nayrton Flávio Moura; Citó, Maria do Carmo de OliveiraObjectives Carvacrol (5-isopropyl-2-methylphenol) is a monoterpenic phenol which is present in the essential oil of oregano and thyme.We have investigated the behavioural effects of carvacrol in animal models of pain, such as acetic acidinduced abdominal constriction, formalin and hot-plate tests in mice. The spontaneous motor activity of animals treated with carvacrol was investigated using open-field and rota...
Adverse reaction caused by drugs acting in nervous system: records analysis of ...
Fonteles, Marta Maria de França; Francelino, Eudiana Vale; Santos, Luciana Kelly Ximenes dos; Silva, Karla Marques; Siqueira, RodrigoBACKGROUND: The morbi-mortality by the use of medicines is a major health problem. The drug adverse reactions may result in death, increased hospitalizations and healthcare costs. OBJECTIVES: Describe and analyze reports of suspected adverse reactions caused by drugs that act on the nervous system (SN-ADR), registered in the database of the Pharmacovigilance Centre of Ceará, from January 1997 to March 2008. MET...
Ecstasy (MDMA): pharmacological and toxic effects, mechanism of action and clin...
Xavier, Caroline Addison Carvalho; Lobo, Patrícia Leal Dantas; Fonteles, Marta Maria de França; Vasconcelos, Silvânia Maria Mendes deBACKGROUND: The consumption of the amphetamine derivative 3,4-methylenedioxymethamphetamine (MDMA, ecstasy) by young people increased in the past years. OBJECTIVES: To conduct a literature review on the pharmacology of MDMA and particularly with respect to the putative mechanism of action implicated in the acute and long-term toxicity and neurotoxic effects. METHODS: A literature review using the key words: 3,4...