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Kinetic and equilibrium mechanisms of substrate binding to Mycobacterium tuberc...
Vasconcelos,Igor B.; Basso,Luiz A.; Santos,Diógenes S.Tuberculosis (TB) remains the leading cause of mortality due to a single bacterial pathogen, Mycobacterium tuberculosis. There is a need for the development of new antimycobacterial agents. M. tuberculosis 2-trans-enoyl-ACP(CoA) reductase (InhA) is the main target of isoniazid, the most prescribed anti-TB agent. Here we present pre-steady state kinetics and equilibrium data of 2-trans-dodecenoyl-CoA substrate b...
Date: 2010
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Origin: Oasisbr