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Preconditioning with L-alanyl-glutamine reduces hepatic ischemia-reperfusion in...
Araújo Júnior,Raimundo José Cunha; Silva Júnior,Raimundo Gerônimo da; Vasconcelos,Marcelo Pinho Pessoa de; Guimarães,Sérgio BotelhoPURPOSE: To evaluate the effects of pre-conditioning with L-alanyl- glutamine (L-Ala-Gln) in rats subjected to total hepatic ischemia. METHODS: Thirty Wistar rats, average weight 300g, were randomly assigned to 3 groups (n=10): G-1 - Saline, G-2- L-Ala-Gln, G-3-control (Sham). G-1 and G-3 groups were treated with saline 2.0 ml or L-Ala-Gln (0.75mg/Kg) intraperitoneally (ip) respectively, 2 hours before laparoto...
Acute pulmonary injury induced by experimental muscle trauma
Sombra,Márcia Andréa da Silva Carvalho; Vasconcelos,Marcelo Pinho Pessoa de; Guimarães,Sergio Botelho; Escalante,Rodrigo DornfeldPURPOSE: To develop an easily reproducible model of acute lung injury due to experimental muscle trauma in healthy rats. METHODS: Eighteen adult Wistar rats were randomized in 3 groups (n=6): G-1- control, G-2 - saline+trauma and G-3 - dexamethasone+trauma. Groups G-1 and G-2 were treated with saline 2,0ml i.p; G-3 rats were treated with dexamethasone (DE) (2 mg/kg body weight i.p.). Saline and DE were applied ...