55 documents found, page 1 of 6
Preconditioning with L-Ala-Gln reduces the expression of inflammatory markers (...
Oliveira,Leidelamar Rosário Alves de; Albuquerque,Andréa de Oliveira; Silva,Cícero Igor Simões Moura; Silva,Jussara MathieleAbstract Purpose To evaluate the neuroprotective effect of L-alanyl-glutamine in a gerbil model of brain ischemia-reperfusion injury based on immunohistochemical quantification of pro-inflammatory and cell activation biomarkers (TNF-α, NF-κB, IL-6 and HO-1). Methods Male gerbils weighing 100-180 g were pretreated with either 0.75 g/kg L-Ala-Gln (n=18) or 2.0 mL saline (n=18) administered i.v. 30 minutes before ...
Comparative study on the efficacy of non-steroidal, steroid and non-use of anti...
Santiago,Luiz Alfredo; Silva,Jussara Matyelle Rodrigues da; Azevedo,Orleâncio Gomes Ripardo de; Vasconcelos,Paulo Roberto Leitão deAbstract Purpose To evaluate the effects of prednisolone against sodium diclofenac both with ciprofloxacin compared to artificial tears on the symptoms and signs of acute viral conjunctivitis. Methods Study included 37 patients diagnosed with acute conjunctivitis and distributed by three groups: A (1% prednisolone acetate + ciprofloxacin (0.3%); B (Sodium diclofenac (0.1%) + ciprofloxacin (0.3%) and C (artifici...
Relevance of prognostic factors in the decision-making of stem cell transplanta...
Duarte,Fernando Barroso; Santos,Talyta Ellen de Jesus dos; Barbosa,Maritza Cavalcante; Kaufman,Jacques; Vasconcelos,João Paulo deABSTRACT The hematopoietic stem cell transplantation (HSCT) is the only curative alternative for Myelodysplastic Syndrome (MDS), but many patients are not eligible for this treatment, as there are several limiting factors, especially in the case of patients with low-risk MDS. The aim of this study is to discuss the factors that can guide the decision-making on referring or not a patient to HSCT. Three cases of ...
Association of oxidative stress and DNA damage with grafting time in patients w...
Santos,Thayna Nogueira dos; Duarte,Fernando Barroso; Maia Filho,Pedro Aurio; Santos,Talyta Ellen de Jesus dos; Barbosa,Maritza CavalcanteABSTRACT The aim of the study was to investigate the association between oxidative stress and DNA damage with grafting time in patients submitted to autologous hematopoietic stem-cell transplantation (HSCT). The study included 37 patients submitted to autologous HSCT diagnosed with Multiple Myeloma (MM) and lymphoma (Hodgkin’s and non-Hodgkin’s). Biomarkers of oxidative stress and DNA damage index (DI) were per...
Development of a subcutaneous endometriosis rat model
Pereira,Francisco Edson Ximenes Gomes; Almeida,Paulo Roberto Carvalho de; Dias,Bruno Hállan Meneses; Vasconcelos,Paulo Roberto Leitão dePURPOSE:To present a rat model of subcutaneous endometriosis for the study of pathophysiology and the effects of drugs.METHODS: Fifty three-month-old female Wistar rats (Rattus norvergicus) were distributed into one control group and four treatment groups: estradiol (2.5; 5; 10mg/kg sc), medroxyprogesterone acetate (0.5; 2; 5mg/kg sc), triptorelin pamoate (0.18; 0.56mg/kg sc) and acetylsalicylic acid (3mg/kg pe...
Preconditioning with mono and polyunsaturated fatty acids and low-intensity ele...
Cardoso,Maria dos Prazeres Carneiro; Albuquerque,Andréa de Oliveira; Girão,Virginia Claudia Carneiro; Pompeu,Margarida Maria de LimaPURPOSE: To evaluate the effects of preconditioning with oils mixes containing ω3/ω6/ω9 associated with micro-currents on skin repair in rats. METHODS: One-hundred and eight Wistar rats randomized into G-1, G-2 and G-3 groups were treated with saline (0.9%), mix 1 (corn+soybean oils) and mix 2 (olive+canola+flaxseed oils), respectively, in a single dose (0.01ml/g) by gavage. Next, each group was subdivided into...
Preconditioning with L-alanyl-glutamine upon cerebral edema and hypocampus red ...
Vasconcelos,Paulo Roberto Cavalcante de; Guimarães,André Brito Bastos; Campelo,Marcio Wilker Soares; Vasconcelos,Paulo Roberto Leitão dePURPOSE:To evaluate the effects of the dipeptide L-alanyl-glutamine (L-Ala-Gln) as a preconditioning agent to potentially promote reduction in the intensity of lesion or induction of resilience in rats subjected to global cerebral ischemia/reperfusion (I/R) injury.METHODS:Thirty-six male Wistar rats weighing 280-300g were randomly assigned to six groups (n=6). Groups Sham 1h and 24h were treated with saline and...
Fructo-oligosaccharide effects on serum cholesterol levels. An overview
Costa,Graciana Teixeira; Abreu,Giselle Castro de; Guimarães,André Brito Bastos; Vasconcelos,Paulo Roberto Leitão de; Guimarães,Sergio BotelhoPURPOSE:To address the effects of fructooligosaccharides (FOS) intake on serum cholesterol levels.METHODS: We performed a search for scientific articles in MEDLINE database from 1987 to 2014, using the following English keywords: fructooligosaccharides; fructooligosaccharides and cholesterol. A total of 493 articles were found. After careful selection and exclusion of duplicate articles 34 references were selec...
Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of therma...
Campelo,Ana Paula Bomfim Soares; Campelo,Márcio Wilker Soares; Brito,Gerly Anne de Castro; Jamacaru,Francisco Vagnaldo FechinePURPOSE: To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury.METHODS:Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (A...
Glutamine and ornithine alpha-ketoglutarate supplementation on malate dehydroge...
Guimarães Filho,Artur; Cunha,Rodrigo Maranguape Silva da; Vasconcelos,Paulo Roberto Leitão de; Guimarães,Sergio BotelhoPURPOSE: To evaluate the relative gene expression (RGE) of cytosolic (MDH1) and mitochondrial (MDH2) malate dehydrogenases enzymes in partially hepatectomized rats after glutamine (GLN) or ornithine alpha-ketoglutarate (OKG) suplementation. METHODS: One-hundred and eight male Wistar rats were randomly distributed into six groups (n=18): CCaL, GLNL and OKGL and fed calcium caseinate (CCa), GLN and OKG, 0.5g/Kg b...