6 documents found, page 1 of 1
loysia citrodora extract as a chemopreventive agent against HPV16-induced lesio...
Medeiros-Fonseca, Beatriz; Faustino-Rocha, Ana I; Silva, Jessica; Pires, Maria João; Neuparth, Maria João; Vala, Helena; Vasconcelos-Nóbrega, CarmenAim: Aloysia citrodora has a long history of traditional use in treating various ailments. This study evaluated the in vivo chemopreventive efficacy and systemic toxicity of an extract of A. citrodora in a transgenic mouse model of HPV16 (human papillomavirus type 16)-induced cancer. Methods: The experiment involved six groups (n = 5): group 1 (G1, wild-type (WT), water), group 2 (G2, HPV, water), group 3 (G3, ...
Parasitas Pulmonares em Pequenos Ruminantes: Mais Conhecimento, Melhor Diagnóstico
Aires Pereira, Maria; Mega, Cristina; Garcês, Andreia; Santos, Carla; Vasconcelos-Nóbrega, Carmen; Melo, Carolina; Rosário Coelho, CarolinaA pneumonia parasitária por nematodes da superfamília Trichostrongyloidea e Metastrongyloidea, também conhecida como estrongilose pulmonar, apresenta elevada prevalência nalgumas regiões geográficas, mas tem merecido pouca atenção por parte dos Médicos Veterinários e investigadores [1,2]. Os estudos de prevalência disponíveis assentam predominantemente na deteção de lesões pulmonares em matadouro e no diagnósti...
Quercus spp. extract as a promising preventive or therapeutic strategy for canc...
Oliveira, Paula; Medeiros-Fonseca, Beatriz; Vasconcelos-Nóbrega, Carmen; Alvarado, Antonieta; Pires, Maria; Vala, Helena; Barros, AnaAcorns have traditionally been used in the human diet and for the treatment of specific diseases. Therefore, the present study performed a systematic review of studies which investigated the effects of Quercus spp. extracts in cancer prevention and treatment. A systematic literature search was performed for original records which addressed the anticancer effects of Quercus spp. extract in in vitro and in vivo c...
N-methyl-N-nitrosourea toxicology: data from a rat model
Vala, Helena; Vasconcelos-Nóbrega, Carmen; Gama, Adelina; Ferreira, Rita; Oliveira, Paula Alexandra; Faustino-Rocha, Ana IsabelIntroduction: N-methyl-N-nitrosourea (MNU) is the oldest member of the nitroso-compounds that can alkylate DNA. MNU induces tumor development in several organs, depending on the animals’ specie and strain, dose, route, and age at administration. Aims: This study aimed to address the toxicological effects of MNU administration in female rats. Methods: Twelve Sprague-Dawley female rats were divided into two exper...
Histopathological features of organs in a rat model of mammary carcinogenesis: ...
Helena, Vala; Vasconcelos-Nóbrega, Carmen; Gama, Adelina; Ferreira, Rita; Oliveira, Paula Alexandra; Faustino-Rocha, Ana IsabelMammary tumors’ development was induced through the intraperioneal administration of the carcinogen N-methyl-N-nitrosourea (MNU). Animals from group control were injected with the vehicle (saline solution). Animals were sacrificed at 25 weeks-old and the organs were histopathologically evaluated. A higher number of lesions was observed in the organs of animals from group MNU. The animals from group control did ...
In vivo and in vitro effects of RAD001 on bladder cancer
Vasconcelos-Nóbrega, Carmen; Pinto-Leite, Rosário; Arantes-Rodrigues, Regina; Ferreira, Rita; Brochado, Paulo; Cardoso, Maria L.; Palmeira, CarlosObjective: To evaluate the influence of Everolimus (RAD001) on chemically induced urothelial lesions in mice and its influence on in vitro human bladder cancer cell lines. Methods: ICR male mice were given N-butyl-N-(4-hydroxybutyl) nitrosamine in drinking water for a period of 12 weeks. Subsequently, RAD001 was administered via oral gavage, for 6 weeks. At the end of the experiment, all the animals were sacrif...