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Transcriptomic-Based Classification Identifies Prognostic Subtypes and Therapeu...
Esperança-Martins, Miguel; Vasques, Hugo; Ravasqueira, Manuel Sokolov; Lemos, Maria Manuel; Fonseca, Filipa; Coutinho, Diogo; López, Jorge AntonioFunding Information: This research was sponsored by F.Hoffmann-LaRoche AG and by Foundation Medicine Inc. under the RNA LDT Research Programme. Funding Information: We would like to thank F.Hoffmann-LaRoche AG and Foundation Medicine Inc. for providing the FoundationOneCDx and FoundationOneRNA assays, and for all the technical support, specifically during the transfer of the sequencing data via the safe platfor...
Ibero-American Consensus for the Management of Liver Metastases of Soft Tissue ...
Lopes Brás, Raquel; Muñoz Muñoz, Paula; Netto, Eduardo; Fernandez, Juan Angel; Serradilla, Mario; Lozano Lominchar, Pablo; Esperança Martins , MiguelPublisher Copyright: © 2025 by the authors.; Liver metastases from soft tissue sarcoma are very rare. The standard treatment for metastatic sarcoma is primarily based on chemotherapy, often with poor results. However, when metastases are confined to the liver and are amenable to surgery or ablative techniques, radical treatment could be an option, keeping patients disease-free and without the need for systemic ...
Practical Guidance on the Detection of NTRK Fusions in Sarcomas
Fernandes, Isabel; Macedo, Daniela; Gouveia, Emanuel; Ferreira, Ana; Lima, Jorge; Lopez, Dolores; Melo-Alvim, Cecília; Carvalho, Alice; Tavares, PauloPublisher Copyright: © 2025 CELOM. All rights reserved.; Sarcomas are a rare and heterogeneous group of mesenchymal malignant tumors and account for approximately 1% of all adult cancers and around 20% of all pediatric solid tumors in Europe. Technology advances have enabled a more accurate and efficient characterization of the molecular mechanisms underlying the pathogenesis of sarcoma subtypes and revealed no...
Succinate Dehydrogenase B (SDHB) Overexpression with Enzymatic Dysfunction Defi...
Esperança-Martins, Miguel; Vasques, Hugo; Ravasqueira, Manuel Sokolov; Santos, Filipa; Fonseca, Filipa; Queiroz, António Syder; Boavida, JoãoPublisher Copyright: ©2025 The Authors; Published by the American Association for Cancer Research.; Undifferentiated pleomorphic sarcoma (UPS) remains one of the most clinically aggressive and poorly characterized soft-tissue sarcoma subtypes. To uncover distinctive molecular traits for UPS, a multiomics analysis of UPS compared with leiomyosarcoma (LMS) and liposarcoma (LPS) was performed. Transcriptomic profi...