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Urinary Mass Spectrometry Profiles in Age-Related Macular Degeneration

Laíns, Inês; Mendez, Kevin M; Gil, João Q.; Miller, John B; Kelly, Rachel S; Barreto, Patrícia Susana Correia Lopes; Kim, Ivana K; Vavvas, Demetrios G

We and others have shown that patients with different severity stages of age-related macular degeneration (AMD) have distinct plasma metabolomic profiles compared to controls. Urine is a biofluid that can be obtained non-invasively and, in other fields, urine metabolomics has been proposed as a feasible alternative to plasma biomarkers. However, no studies have applied urinary mass spectrometry (MS) metabolomic...


Novel grid combined with peripheral distortion correction for ultra-widefield i...

Oellers, Patrick; Laíns, Inês; Mach, Steven; Garas, Shady; Kim, Ivana K; Vavvas, Demetrios G; Miller, Joan W; Husain, Deeba; Miller, John B

Purpose: Eyes with age-related macular degeneration (AMD) often harbor pathological changes in the retinal periphery and perimacular region. These extramacular changes have not been well classified, but may be phenotypically and functionally relevant. The purpose of this study was to demonstrate a novel grid to systematically study peripheral retinal abnormalities in AMD using geometric distortion-corrected ult...


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