CAPES - Coordenação de Aperfeiçoamento de Pessoal de Nível Superior; A resposta alérgica é caracterizada pelo reconhecimento de alérgenos e ativação do sistema imunológico. Um alérgeno, irá ativar células para que haja a produção de citocinas inflamatórias, diferenciação de linfócitos T para um perfil Th2, ativação de linfócitos B para a produção de IgE e liberação de moléculas inflamatórias. Uma vez desencadea...
Autoimmune diseases are a group of different diseases which are characterized by an immune disorder leading to decreased tolerance to components of the body itself. These diseases have many factors that trigger such as a decrease of the share or percentage of regulatory T cells (Tregs). The Transforming Growth Factor-beta 1 (TGF-β1) is involved in the suppression of the inflammatory response during the pathogen...
Introduction: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects around 1% of the human population worldwide. RA diagnosis can be difficult as there is no definitive test for its detection. Therefore, the aim of this study was to identify biomarkers that could be used for RA diagnosis. Methods: Sera from a collagen-induced arthritis mouse model were used to select potential biom...